Gene interactions and pathways from curated databases and text-mining

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DCP2 — EXOSC2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ingham et al., Mol Microbiol 1999 : Rho was not involved in bulk mRNA decay in B. subtilis
Barnhart et al., J Immunol 2000 : CD154 expression is regulated throughout a time course of CD3 dependent T cell activation by differential mRNA decay
Bond et al., Mol Cell Biol 2001 : We propose a unifying model in which Dbp2p affects both nonsense mediated mRNA decay and rRNA processing by altering rRNA structure, allowing specific processing events in one instance and facilitating dissociation of the translation termination complex in the other
Maillet et al., J Biol Chem 2002 : Taken together, our results suggest that the Ccr4-Not complex , via the N-terminal region of Not1p, is necessary for the maintenance of stable cellular levels of Dhh1p and Caf1p, thus contributing to regulation of mRNA decay in addition to transcription
Bollig et al., Biochem Biophys Res Commun 2003 : The selective interaction with an ARE containing RNA and the phosphorylation by MK2 suggest that PABP1 plays a regulatory role in ARE dependent mRNA decay and its modulation by the p38 MAP kinase cascade
Smith et al., J Gen Virol 2003 (Herpes Simplex) : This paper examines whether RNase L , a virally induced endoribonuclease, contributes to HSV induced mRNA decay
Long et al., Mol Cell 2003 : In yeast, Dcp1p, Dcp2p, Lsm1-7p , and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay ... In yeast, Dcp1p, Dcp2p , Lsm1-7p, and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay ... In yeast, Dcp1p , Dcp2p, Lsm1-7p, and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay ... In yeast, Dcp1p, Dcp2p, Lsm1-7p, and Xrn1p are required for mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay
Takahashi et al., EMBO J 2003 : Interaction between Ski7p and Upf1p is required for nonsense mediated 3'-to-5 ' mRNA decay in yeast
Uchida et al., J Biol Chem 2004 : Consistent with the roles of hPan2 and hPan3 in mRNA decay , the two subunits exhibit cytoplasmic co-localization ... Consistent with the roles of hPan2 and hPan3 in mRNA decay , the two subunits exhibit cytoplasmic co-localization
Shibuya et al., Nature structural & molecular biology 2004 : In mammalian cells, eIF4AIII is essential for nonsense mediated mRNA decay ( NMD )
Gherzi et al., Mol Cell 2004 : Thus, KHs promote rapid mRNA decay by recruiting degradation machinery to ARE containing mRNAs
Yang et al., J Biol Chem 2004 : Endonuclease mediated mRNA decay requires tyrosine phosphorylation of polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome bound substrate mRNA
Unterholzner et al., Mol Cell 2004 : In contrast, SMG5 requires SMG7 to trigger mRNA decay and to localize to decay bodies
Ogilvie et al., J Immunol 2005 : We hypothesized that the ARE binding protein tristetraprolin (TTP) regulates T lymphocyte IL-2 mRNA decay by interacting with the IL-2 ARE and targeting the transcript for decay
Lykke-Andersen et al., Genes Dev 2005 : TTP and BRF-1 each contain two activation domains that can activate mRNA decay after fusion to a heterologous RNA binding protein, and inhibit ARE mediated mRNA decay when overexpressed ... TTP and BRF-1 each contain two activation domains that can activate mRNA decay after fusion to a heterologous RNA binding protein, and inhibit ARE mediated mRNA decay when overexpressed
Bonafé et al., Cancer Res 2005 (Ovarian Neoplasms) : These data suggest that GAPDH binding to CSF-1 ARE sequence prevents CSF-1 mRNA decay and subsequent down-regulation of CSF-1 protein translation, leading to CSF-1 overexpression and increased metastatic properties seen in ovarian cancer
Culbertson et al., RNA 2005 : In Saccharomyces cerevisiae, nonsense mediated mRNA decay ( NMD ) requires Upf1p , Upf2p, and Upf3p to accelerate the decay rate of two unique classes of transcripts : ( 1 ) nonsense mRNAs that arise through errors in gene expression, and ( 2 ) naturally occurring transcripts that lack coding errors but have built-in features that target them for accelerated decay ( error-free mRNAs )
Khan et al., Carcinogenesis 2006 (Xeroderma Pigmentosum) : This reduced XPC mRNA level in cells from XP-C patients was caused by the PTC that induces nonsense mediated mRNA decay
Gaba et al., Mol Cell 2005 : CPA1 expression is also controlled by nonsense mediated mRNA decay ( NMD )
Yamashita et al., Biochim Biophys Acta 2005 : The role of SMG-1 in nonsense mediated mRNA decay
Kwak et al., J Biol Chem 2006 : Our results indicate that mPer3 3'-UTR mediated mRNA decay plays an essential role in mRNA cycling and provide direct evidence for post-transcriptional control of circadian mRNA oscillations
Goldstrohm et al., Nature structural & molecular biology 2006 : We suggest that the PUF-Pop2p interaction underlies regulated deadenylation, mRNA decay and repression by PUF proteins
Lee et al., Neurobiol Dis 2006 (Disease Models, Animal...) : Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy ( GLD ) is caused by nonsense mediated mRNA decay ( NMD )
Seko et al., Autoimmun Rev 2006 (Autoimmune Diseases) : Cytokine mRNA decay is dependent not only upon cis-elements in the RNA but also upon trans acting factors such as the RNA binding proteins TTP, HuR, AUF-1, Nucleolin and YB-1
Arciga-Reyes et al., Plant J 2006 : UPF1 is required for nonsense mediated mRNA decay ( NMD ) and RNAi in Arabidopsis
Jang et al., J Biol Chem 2006 : In addition, Rbp1p mediated porin mRNA decay is elicited by Xrn1p, a 5 ` to 3 ` exonuclease
He et al., EMBO J 2006 : AUF1 proteins bind the ARE, undergo shuttling, and promote cytoplasmic ARE-mRNA decay through a poorly understood mechanism
Huertas et al., Mol Cell Biol 2006 : The lack of a functional THO complex impairs transcription, leads to transcription dependent hyperrecombination, causes mRNA export defects and fast mRNA decay , and retards replication fork progression in a transcription dependent manner
Benjamin et al., Mol Cell Biol 2006 : BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
Mohanty et al., Nucleic Acids Res 2006 : Polyadenylation of RNAs by poly ( A ) polymerase I ( PAP I ) in Escherichia coli plays a significant role in mRNA decay and general RNA quality control
Hau et al., J Cell Biochem 2007 : A 31 nucleotide ARE sequences from the TNF-alpha 3 ' UTR promoted TTP dependent mRNA decay when it was inserted into the 3 ' UTR of a beta-globin reporter transcript, indicating that this short sequence was sufficient for TTP function
Urban et al., Nucleic Acids Res 2007 : We found that translational regulation by these sRNAs was largely independent of full-length RNase E, e.g. despite the fact that ompA fusion mRNA decay could no longer be promoted by MicA
Behm-Ansmant et al., EMBO J 2007 : A conserved role for cytoplasmic poly(A) binding protein 1 ( PABPC1 ) in nonsense mediated mRNA decay
Peng et al., Mol Cell 2007 : c-Src activates endonuclease mediated mRNA decay ... Similarly, only active c-Src induces PMR1 mediated mRNA decay
Morris et al., EMBO Rep 2007 : Human INT6/eIF3e is required for nonsense mediated mRNA decay
Stojic et al., BMC molecular biology 2007 : While inhibition of nonsense mediated mRNA decay selectively stabilized ABCC5_SV1 but not ABCC5_SV2, the amount of full length ABCC5 mRNA was simultaneously reduced
Deleault et al., Mol Immunol 2008 (MAP Kinase Signaling System) : These data establish that TTP mediated TNF-alpha mRNA decay is inhibited by the combined activation of ERK and p38 and not by p38 activation alone
Yamasaki et al., J Biol Chem 2007 : Tethering TIA-1 to a reporter transcript also promotes mRNA decay , suggesting that TIA-1 mediated translational silencing can render mRNA susceptible to the decay machinery
Simón et al., Nucleic Acids Res 2007 : Overall, our results demonstrate a direct involvement of Pab1 in mRNA decay and reveal the modular nature of this factor, with different domains affecting various cellular processes
Luke et al., Nucleic Acids Res 2007 : Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense mediated mRNA decay
Müller et al., J Cell Biol 2007 : Histone mRNA decay does not require Chk1/Chk2
Meaux et al., Mol Cell 2008 : Nonsense mediated mRNA decay in yeast does not require PAB1 or a poly ( A ) tail
Zhu et al., RNA Biol 2008 : In this article, we will review the work to date in understanding the mechanisms by which ZAP promotes viral mRNA decay and discuss future research directions to further investigate the function and underlying mechanisms of ZAP
Woo et al., Nucleic Acids Res 2009 : This report on the regulation of mper2 proposes that post-transcriptional mRNA decay mediated by PTB is a fine tuned regulatory mechanism that includes dampening-down effects during circadian mRNA oscillations
Gong et al., Genes Dev 2009 : UPF1 functions in both Staufen 1 (STAU1) mediated mRNA decay ( SMD ) and nonsense mediated mRNA decay ( NMD ), which we show here are competitive pathways
Ogilvie et al., J Biol Chem 2009 : Tristetraprolin mediates interferon-gamma mRNA decay
Vignier et al., Circ Res 2009 (Disease Models, Animal...) : Nonsense mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin binding protein C mutant levels in cardiomyopathic mice
Sanduja et al., Aging 2009 (Uterine Cervical Neoplasms) : It was found that TTP promoted rapid mRNA decay of the cellular ubiquitin ligase E6-associated protein ( E6-AP )
Zhou et al., Nucleic Acids Res 2010 (Prostatic Neoplasms) : Here we show that EBP1 promoted AR mRNA decay through physical interaction with a conserved UC-rich motif within the 3'-UTR of AR
Burnicka-Turek et al., BMC cell biology 2010 : Recent studies revealed the essential role of PELO in the No-Go mRNA decay , by which mRNA with translational stall are endonucleotically cleaved and degraded
Temme et al., RNA 2010 : Overexpression of catalytically dead CAF1 had a dominant negative effect on mRNA decay
Li et al., RNA 2011 : Using mouse embryonic fibroblast (MEF) cell lines derived from a hypomorphic knockout of the Dcp2 gene with undetectable levels of Dcp2 or MEF cell lines harboring a Nudt16 directed shRNA to generate reduced levels of Nudt16, we demonstrate the distinct roles for Dcp2 and Nudt16 in nonsense mediated mRNA decay ( NMD ), decay of ARE containing mRNA and miRNA mediated silencing ... Using mouse embryonic fibroblast (MEF) cell lines derived from a hypomorphic knockout of the Dcp2 gene with undetectable levels of Dcp2 or MEF cell lines harboring a Nudt16 directed shRNA to generate reduced levels of Nudt16, we demonstrate the distinct roles for Dcp2 and Nudt16 in nonsense mediated mRNA decay ( NMD ), decay of ARE containing mRNA and miRNA mediated silencing
Sanduja et al., Wiley Interdiscip Rev RNA 2011 (Inflammation...) : The roles of TTP and BRF proteins in regulated mRNA decay ... The roles of TTP and BRF proteins in regulated mRNA decay
Jinek et al., Mol Cell 2011 : Coupled 5 ' nucleotide recognition and processivity in Xrn1 mediated mRNA decay
Sugiyama et al., J Biochem 2011 : Here, we report that the interaction between Mrt4 and Yvh1 is also essential for normal glycogen accumulation and mRNA decay as well as the induction of sporulation genes IME2, SPO13 and HOP1
Lin et al., J Cell Biol 2011 : Here we show that down-regulation of PTB and its neuronal analogue nPTB during muscle cell differentiation may involve alternative splicing coupled nonsense mediated mRNA decay
Lin et al., Mol Cell Biol 2011 (Herpes Simplex...) : Here we show that mouse embryonic fibroblasts derived from knockout mice deficient in KH-type splicing regulatory protein ( KSRP ), an RNA binding protein required for ARE mediated mRNA decay, produce higher levels of Ifna and Ifnb mRNAs in response to viral infection as a result of decreased mRNA decay ... Here we show that mouse embryonic fibroblasts derived from knockout mice deficient in KH-type splicing regulatory protein ( KSRP ), an RNA binding protein required for ARE mediated mRNA decay, produce higher levels of Ifna and Ifnb mRNAs in response to viral infection as a result of decreased mRNA decay
Kim et al., Nucleic Acids Res 2011 : hnRNP Q mediates a phase dependent translation coupled mRNA decay of mouse Period3 ... We propose the phase dependent translation coupled mRNA decay mediated by hnRNP Q as a new regulatory mechanism of the rhythmically regulated decay of mPer3 mRNA
Challagundla et al., Mol Cell Biol 2011 : Ablation of Ago2 abrogated the L11 mediated reduction of c-myc mRNA, whereas knockdown of L11 rescued miR-24 mediated c-myc mRNA decay
Carroll et al., J Cell Biol 2011 : Whereas Dhh1 's ATPase activity was not required to induce translational inhibition and mRNA decay when directly tethered to an mRNA, ATP hydrolysis regulated processing body dynamics and the release of Dhh1 from these RNA-protein granules ... Whereas Dhh1 's ATPase activity was not required to induce translational inhibition and mRNA decay when directly tethered to an mRNA, ATP hydrolysis regulated processing body dynamics and the release of Dhh1 from these RNA-protein granules
Gherzi et al., Wiley Interdiscip Rev RNA 2010 : The role of KSRP in mRNA decay and microRNA precursor maturation
Gratacós et al., Wiley Interdiscip Rev RNA 2010 : The role of AUF1 in regulated mRNA decay
Chang et al., Nucleic Acids Res 2012 : Here, we show that Dhh1p can associate with POR1 mRNA and specifically promote POR1 mRNA decay via its interaction with Rbp1p ... Interestingly, this non conserved C-terminal region of Dhh1p is required for interaction with Rbp1p and modulating Rbp1p mediated POR1 mRNA decay ... Moreover, mammalian DDX6 became capable of interacting with Rbp1p and could confer Rbp1p mediated POR1 mRNA decay in the dhh1d strain upon fusion to the C-terminal unique region of Dhh1p
Young et al., Mol Cancer Res 2012 (Carcinoma...) : We identified miR-16 to bind the COX-2 3'-UTR and inhibit COX-2 expression by promoting rapid mRNA decay
Masuda et al., Scientific reports 2012 : Role of CUGBP1 on accelerated mRNA decay has been previously reported, but the similar function of MBNL1 has not been reported to date
Mocquet et al., J Virol 2012 : The human T-lymphotropic virus type 1 tax protein inhibits nonsense mediated mRNA decay by interacting with INT6/EIF3E and UPF1 ... The human T-lymphotropic virus type 1 tax protein inhibits nonsense mediated mRNA decay by interacting with INT6/EIF3E and UPF1
Chujo et al., Nucleic Acids Res 2012 : LRPPRC/SLIRP suppresses PNPase mediated mRNA decay and promotes polyadenylation in human mitochondria ... LRPPRC/SLIRP suppresses PNPase mediated mRNA decay and promotes polyadenylation in human mitochondria
Al-Haj et al., Nucleic Acids Res 2012 : Indeed, we found that RNase L promotes tristetraprolin ( TTP/ZFP36 ) mRNA decay ... The TTP regulation of p21 mRNA decay required functional AU-rich elements
Liu et al., Int J Biochem Cell Biol 2012 (Calcium Signaling) : The reduction in TTP-KH-type splicing regulatory protein ( KSRP ) complexes formation promoted KSRP mediated MMP-2/MMP-9 mRNA decay in CIL-102 treated K562 cells
Zhu et al., EMBO J 2012 : Translational repression precedes and is required for ZAP mediated mRNA decay
Nakamura et al., Nature communications 2012 : Preferential decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt-Cerl2 interlinked feedback loops, in which Wnt3 upregulates Wnt3 expression and promotes Cerl2 mRNA decay , whereas Cerl2 promotes Wnt degradation
Liu et al., Carcinogenesis 2013 (Leukemia) : Moreover, TTP overexpression increased TNF-a mRNA decay in HQ-treated cells
Yamashita et al., Genes Cells 2013 : Role of SMG-1 mediated Upf1 phosphorylation in mammalian nonsense mediated mRNA decay
Woo et al., Mol Cell Proteomics 2013 : Through interaction with the CSF-1 3'UTR miRNA common target, we find that miR-130a and miR-301a inhibit CSF-1 expression by enhancing mRNA decay
Ochs et al., J Proteome Res 2013 : Recently, we have demonstrated that 5-LO mRNA expression is regulated by alternative splicing and nonsense mediated mRNA decay ( NMD )
Leppek et al., Cell 2013 (Inflammation) : Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs
Jin et al., Gene 2013 (Mucopolysaccharidosis II) : In addition, qRT-PCR products from the two patients showed a reduced IDS mRNA expression ( 43.9 % and 71.2 %, respectively ), when compared with the average IDS mRNA expression in healthy control samples, possibly as a result of nonsense mediated mRNA decay
Al-Khalaf et al., PloS one 2013 : p16(INK4A) Positively Regulates p21 ( WAF1 ) Expression by suppressing AUF1 dependent mRNA decay
Lee et al., Proc Natl Acad Sci U S A 1995 : Double disruptions of UPF1 and UPF3 affect nonsense mRNA decay in a manner indistinguishable from single disruptions ... Double disruptions of UPF1 and UPF3 affect nonsense mRNA decay in a manner indistinguishable from single disruptions
Czaplinski et al., RNA 1995 : Based on these results, the role of Upf1p 's biochemical activities in mRNA decay and translation are discussed
Peltz et al., Genes Dev 1993 : Using amber ( UAG ) mutants of the yeast PGK1 gene as a model system, we find that nonsense mediated mRNA decay is position dependent , that is, nonsense mutations within the initial two-thirds of the PGK1 coding region accelerate the decay rate of the PGK1 transcript < or = 12-fold, whereas nonsense mutations within the carboxy-terminal third of the coding region have no effect on mRNA decay
Babitzke et al., J Bacteriol 1993 : In addition, these results indicate that RNase III is probably not required for general mRNA decay
DeMaria et al., J Biol Chem 1996 : These results support a role for AUF1 in ARE directed mRNA decay that is based upon its affinity for different AREs
Weng et al., Mol Cell Biol 1996 : On the basis of these results, the role of the Upf complex in nonsense mediated mRNA decay and nonsense suppression is discussed
Matsunaga et al., Mol Microbiol 1996 : Moreover, mutations in rncO that block RNase III cleavage also block control, showing that RNase III initiates mRNA decay by cleaving at a single site
Ingle et al., Proc Natl Acad Sci U S A 1996 : Exogenously added PAP I does not restore mRNA decay to PAP I-polysomes, suggesting that, in vivo, PAP I may be part of a multiprotein complex
Cruz et al., FEMS Microbiol Lett 1996 : A new role for RNase II in mRNA decay : striking differences between RNase II mutants and similarities with a strain deficient in RNase E
He et al., Mol Cell Biol 1997 : We showed previously that Upf1p and Nmd2p interact and that this interaction is required for nonsense mediated mRNA decay ( F
Christiano et al., J Invest Dermatol 1997 (Epidermolysis Bullosa Dystrophica) : Premature termination codon mutations in the type VII collagen gene in recessive dystrophic epidermolysis bullosa result in nonsense mediated mRNA decay and absence of functional protein
Shirley et al., J Cell Sci 1998 : In Saccharomyces cerevisiae, Upf3p is required for nonsense mediated mRNA decay ( NMD )
Mangus et al., Mol Cell Biol 1998 : The suppression of pab1Delta by pbp1Delta appears to be different from that mediated by other pab1 suppressors, since disruption of PBP1 does not alter translation rates, affect accumulation of ribosomal subunits, change mRNA poly ( A ) tail lengths, or result in a defect in mRNA decay