Gene interactions and pathways from curated databases and text-mining

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EGF — PRKAR2B

Text-mined interactions from Literome

Pursiheimo et al., Proc Natl Acad Sci U S A 2000 : In accordance with the growth factor specificity of FiRE, the activity of PKA was stimulated by FGF-2 but not by platelet derived growth factor or epidermal growth factor
Crépieux et al., Arch Biochem Biophys 2002 : In comparison, in the absence of anchorage, ERK1, 2 were still activated by epidermal growth factor , in a PKA dependent manner
Salazar et al., Mol Biol Cell 2002 : Furthermore, PKA inhibition may contribute to ligand induced EGFR endocytosis because epidermal growth factor inhibited 26 % of PKA basal activity
Sirotkin et al., Reprod Nutr Dev 2002 : The expression of the PKA regulatory subunit was increased by EGF ( 51 % compared with 29 % in the control, p < 0.05 ), but not by IGF-I or IGF-II ( 30 and 29 % )
Yang et al., J Membr Biol 2003 (Calcium Signaling) : EGF induces CCE through its stimulation of Erkl/2 activity, whereas PKA stimulation suppresses these effects of EGF
Fassett et al., Mol Biol Cell 2006 : Inhibition of PKA using H89 increased cell spreading on collagen gel in an EGF dependent manner, whereas activation of PKA using 8-Br-cAMP decreased cell spreading on collagen film
Srisawang et al., Biochim Biophys Acta 2007 : In contrast, activation of PKA by both forskolin and epidermal growth factor (EGF) had no effect on succinate transport
Evaul et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Steroidogenesis in Leydig cells was unaffected by MMP inhibitors, suggesting that cAMP and PKA trans activated EGF receptors in an intracellular fashion