Gene interactions and pathways from curated databases and text-mining

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FGA — IL8

Text-mined interactions from Literome

Lalla et al., Oral Oncol 2001 (Carcinoma, Squamous Cell...) : Fibrinogen , thrombin and collagen were all unable to induce significant IL-8 expression, establishing the specificity of fibrin in causing this response
Kuhns et al., J Immunol 2001 (Leukocyte-Adhesion Deficiency Syndrome) : Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene B ( 4 )
Azizova et al., Bull Exp Biol Med 2007 : Fibrinogen induces IL-8 production in primary culture of endothelial cells from human umbilical vein ; the oxidized form of fibrinogen is more active, similarly as during induction of the expression cell adhesion molecules ( P-selectin and ICAM-1 )