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FGF2 — NOTCH1
Text-mined interactions from Literome
Liu et al., Mol Cell Biol 2003
:
We show here that vascular endothelial growth factor ( VEGF ) but not
basic fibroblast growth factor can
induce gene expression of
Notch1 and its ligand, Delta-like 4 (Dll4), in human arterial endothelial cells
Small et al., J Biol Chem 2003
(Cell Transformation, Neoplastic) :
Notch activation
suppresses fibroblast growth factor dependent cellular transformation
Akai et al., Genes Dev 2005
:
FGF dependent
Notch signaling maintains the spinal cord stem zone
Ever et al., Dev Neurosci 2008
:
Based upon our prior finding that
Notch1 activation
increased neurosphere frequency in
FGF2 , we tested whether this effect is mediated by FGFR1 or FGFR2
Nakajima et al., Cell Tissue Res 2008
:
Autonomic neurogenesis is completely prevented by
fibroblast growth factor (FGF)-2 treatment or by
activation of
Notch signaling
Kiec-Wilk et al., J Physiol Pharmacol 2010
:
The MAPK dependent
regulation of the
Jagged/Notch gene expression by VEGF,
bFGF or PPAR gamma mediated angiogenesis in HUVEC
Bae et al., Cardiovasc Res 2011
:
Notch1 mediates visfatin induced
FGF-2 up-regulation and endothelial angiogenesis ... Visfatin also stimulated
fibroblast growth factor-2 (FGF-2) gene expression in a
Notch1 dependent manner ... Our data provide the first example of
Notch1 dependent endothelial
FGF-2 induction by visfatin and of Notch1 activation in visfatin stimulated endothelial angiogenesis, suggesting that the signalling axis of visfatin/Notch1/angiogenic factors like FGF-2 might be a valuable target for pathological angiogenesis
Serrano et al., Arch Oral Biol 2011
:
Exogenous
FGF-2 up-regulated
Notch 1 , Twist 1 and Twist 2 gene expression in MCC explants from E17 mice, whilst TGF-ß2 had the opposite effect
Lopez et al., Proc Natl Acad Sci U S A 2013
(Wnt Signaling Pathway) :
Notch clock activity is
suppressed in the posterior PSM by
FGF signaling until it crosses a determination front at which its net activity is sufficiently high to effect segmentation