Gene interactions and pathways from curated databases and text-mining

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FGFR1 — PI3

Text-mined interactions from Literome

Hart et al., Oncogene 2000 (Cell Transformation, Neoplastic) : Finally, we demonstrate that FGFR1 , FGFR3, and FGFR4 derivatives can stimulate PI-3 kinase activity ... Finally, we demonstrate that FGFR1, FGFR3 , and FGFR4 derivatives can stimulate PI-3 kinase activity
Shi et al., Zhonghua Yi Xue Za Zhi 2004 (Breast Neoplasms) : T47D cells were inoculated into a 24-well plate, co-transfected with luciferase vector OB-HRE containing HIF-1 functional sequence ( HRE ) and pRL-SV40 ( as inner marker ), pretreated with SU5402, inhibitor of FGFR1 , SB203580, inhibitors of PI-3K , PD98059, inhibitors of MEK1, or LY294002, inhibitors of p38, treated with basic fibroblast growth factor (bFGF), and then lysed
Mavila et al., PloS one 2012 (Liver Neoplasms) : FGF Receptor ( R ) activation resulted in the downstream activation of MAPK, PI3K-AKT , and ß-catenin pathways, as well as cellular proliferation
Landgren et al., Oncogene 1998 : Although the FGFR-1 only very inefficiently mediates activation of phosphatidylinositol 3 ' kinase ( PI 3-kinase ), the PI 3-kinase inhibitor wortmannin suppressed wild-type FGFR-1 mediated migration