Gene interactions and pathways from curated databases and text-mining

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GATA4 — MAPK6

Text-mined interactions from Literome

Kitta et al., Biochem J 2001 : In contrast, the activation of MAPK by phenylephrine or H ( 2 ) O ( 2 ) was weak and did not lead to GATA-4 phosphorylation
Tremblay et al., J Biol Chem 2003 : We now show that the rapid phosphorylation of GATA-4 induced by cAMP in vivo can be blocked by a PKA-specific inhibitor but not by mitogen activated protein kinase inhibitors, indicating that GATA-4 is predominantly phosphorylated by PKA in response to cAMP in gonadal cells
Liu et al., J Cell Sci 2009 : Pharmacological inhibition of ERK1/2 or p38 MAPK blocked vitronectin induced GATA4 nuclear translocation and endoderm maturation, whereas expression of a constitutively active ERK kinase ( MEK1 ) or p38 MAPK in the mutant cells rescued endoderm maturation in integrin-beta1-null endoderm cells
Gierl et al., Dev Cell 2012 (Gonadal Dysgenesis, 46,XY...) : Moreover, the transcription factor GATA4 , which is required for Sry expression, binds to the Sry promoter in vivo in a MAPK dependent manner