Gene interactions and pathways from curated databases and text-mining

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CASP14 — GZMB

Text-mined interactions from Literome

Tepper et al., Blood 1999 (Burkitt Lymphoma) : The apoptotic pathway distal to the DISC is intact because ceramide analogs, staurosporine, and granzyme B activate caspase-3 and induce apoptosis
Pathan et al., J Biol Chem 2001 (Neoplasms) : TUCAN interferes with binding of Apaf1 to procaspase-9 and suppresses caspase activation induced by the Apaf1 activator, cytochrome c. Overexpression of TUCAN in cells by stable or transient transfection inhibits apoptosis and caspase activation induced by Apaf1/caspase-9 dependent stimuli, including Bax, VP16, and staurosporine, but not by Apaf1/caspase-9 independent stimuli, Fas and granzyme B
Jerome et al., J Immunol 2001 : In contrast, caspase 3 activation in mitochondria-free cell lysates by granzyme ( gr ) B was inhibited equivalently by Us5 deletion and rescue viruses, suggesting that gJ is not required for HSV to inhibition this process
Goping et al., Immunity 2003 : Thus granzyme B mediates direct cleavage of caspase 3 and also activates mitochondrial disruption, resulting in the release of proapoptotic proteins that suppress caspase inhibition
Fellows et al., Blood 2007 : Although GzmH is most closely related to the caspase activating granzyme B (GzmB) , neither a natural substrate nor a role in immune defense reactions has been demonstrated for this orphan granzyme
Zapata et al., J Biol Chem 1998 : Since the granzyme B is a direct activator of caspase-3 and its expression is induced following T-cell activation, we tested the effects of anti-GraB, an engineered serpin that specifically inhibits GraB