◀ Back to NFKB1

HBEGF — NFKB1

Text-mined interactions from Literome

Mehta et al., J Immunol 2003 (Inflammation) : HB-EGF dramatically suppressed NF-kappaB activity and IL-8 release and decreased NO production in cells pretreated with HB-EGF ... HB-EGF blocked NF-kappaB activation by inhibiting IkappaB kinase activation and IkappaB phosphorylation and degradation, thus interfering with NF-kappaB nuclear translocation, DNA binding activity, and NF-kappaB dependent transcriptional activity
Mehta et al., J Immunol 2005 (MAP Kinase Signaling System) : Neither overexpression or inhibition of MEK, Ras, or Akt affected HB-EGF mediated inhibition of NF-kappaB activation
Wang et al., Oncogene 2007 (Neoplasms) : Using RNA interference, we demonstrated that the chemotherapy induced HB-EGF was largely dependent on activator protein-1 (AP-1) and NF-kappaB activation