Gene interactions and pathways from curated databases and text-mining

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BCL2 — HDAC1

Text-mined interactions from Literome

Whitecross et al., Blood 2009 (Lymphoma) : The apoptotic and therapeutic activities of the histone deacetylase inhibitor ( HDACi ) vorinostat are blocked by overexpression of Bcl-2 or Bcl-X ( L )
Martin et al., Mol Pharmacol 2009 : BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing
Jin et al., Journal of gynecologic oncology 2010 : Importantly, both HDAC inhibitors dose-dependently inhibited the expression of the antiapoptotic proteins Bcl-2 and x-linked inhibitor of apoptosis protein ( XIAP )
Ramsey et al., Cancer Res 2011 (Carcinoma, Squamous Cell) : Repression of proapoptotic Bcl-2 family member genes including p53 upregulated modulator of apoptosis ( PUMA ) by p63/HDAC is required for survival of SCC cells
Yi et al., Chemotherapy 2012 (Carcinoma...) : DNMT inhibitors and HDAC inhibitors regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo