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HEY1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Huang et al., Proc Natl Acad Sci U S A 2004
(Cell Transformation, Neoplastic) :
HES1,
HEY1 , and TFAP4, which are members of the basic helix-loop-helix transcription family, and OSR1 were shown to
activate p53 through repression of HDM2 transcription ... Furthermore, ras- and myc mediated transformation of mouse embryonic fibroblasts was abrogated by expression of
HEY1 in a
p53 dependent manner
Ban et al., Cancer Res 2008
(Sarcoma, Ewing) :
Conversely, forced expression of JAG1, activated NOTCH3, or
HEY1 induced
p53 and p21 ( WAF1/CIP1 )
Villaronga et al., Oncogene 2010
:
The polymorphism Leu94Met also abolishes
HEY1 mediated activation of
p53 and suppresses the ability of HEY1 to induce p53 dependent cell-cycle arrest and aberrant cell differentiation in human osteosarcoma U2OS cells
López-Mateo et al., Cell cycle (Georgetown, Tex.) 2012
:
On the other hand, partial depletion of endogenous CREBZF diminishes
p53 protein levels and
inhibits HEY1 mediated activation of p53