Gene interactions and pathways from curated databases and text-mining

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HEY1 — TP53

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Huang et al., Proc Natl Acad Sci U S A 2004 (Cell Transformation, Neoplastic) : HES1, HEY1 , and TFAP4, which are members of the basic helix-loop-helix transcription family, and OSR1 were shown to activate p53 through repression of HDM2 transcription ... Furthermore, ras- and myc mediated transformation of mouse embryonic fibroblasts was abrogated by expression of HEY1 in a p53 dependent manner
Ban et al., Cancer Res 2008 (Sarcoma, Ewing) : Conversely, forced expression of JAG1, activated NOTCH3, or HEY1 induced p53 and p21 ( WAF1/CIP1 )
Villaronga et al., Oncogene 2010 : The polymorphism Leu94Met also abolishes HEY1 mediated activation of p53 and suppresses the ability of HEY1 to induce p53 dependent cell-cycle arrest and aberrant cell differentiation in human osteosarcoma U2OS cells
López-Mateo et al., Cell cycle (Georgetown, Tex.) 2012 : On the other hand, partial depletion of endogenous CREBZF diminishes p53 protein levels and inhibits HEY1 mediated activation of p53