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HMOX1 — TNF

Text-mined interactions from Literome

Iyer et al., J Biol Chem 2000 : Experiments with HO-1/KO and iNOS/KO mice showed that Allotrap 1258 mediated inhibition of TNF was independent of HO-1 and iNOS
Sass et al., Inflamm Res 2002 (Drug-Induced Liver Injury) : TNF-pretreatment did not affect TNFR-1 expression in the liver and resulted in time dependent up-regulation of iNOS, IL-1beta and HO-1 ... IL-1beta, iNOS and HO-1 neither mediated TNF-tolerance nor TNF cytotoxicity
Song et al., World J Gastroenterol 2003 : LPS induced HO-1 expression is mainly mediated by endogenous TNF-alpha , but only partially by endogenous IL-1beta
Bundy et al., Antioxid Redox Signal 2005 (Inflammation...) : In contrast, hemin and hemoglobin, but neither TNFalpha nor H2O2, caused efficient HO-1 expression
Maeshima et al., Biochem Pharmacol 2005 (Respiratory Distress Syndrome, Adult...) : HA pretreatment markedly induced HO-1 in pulmonary epithelial cells, and ameliorated the lung injury induced by HSR as judged by the improvement of histological changes, while it decreased TNF-alpha and inducible nitric oxide synthase gene expression, lung wet weight to dry weight ratio, and myeloperoxidase activity
Abraham et al., Free Radic Biol Med 2005 (Cardiovascular Diseases...) : HO-1 induction by pharmacological agents or gene transfer of human HO-1 into endothelial cells ( ECs ) in vitro increases cell-cycle progression and attenuates Ang II, TNF- , and heme mediated DNA damage ; administration in vivo acts to correct blood pressure elevation following Ang II exposure
Malaguarnera et al., Int Immunopharmacol 2005 : Moreover, co-stimulation of PRL with LPS caused activation of HMMs functions, enhancement of HO-1 expression and induction of VEGF release, whereas addition of PRL inhibited up-regulation of HO-1 or VEGF induced by IFN-gamma or TNF-alpha
Basuroy et al., Am J Physiol Cell Physiol 2006 : TNF-alpha did not induce HO-1 expression in CMVEC
Mohri et al., J Trauma 2006 (Systemic Inflammatory Response Syndrome) : Expression of HO-1 , TLR2, and TLR4 in monocytes was significantly enhanced in patients with severe SIRS compared with that in healthy volunteers, whereas intracellular TNF-alpha expression with peptidoglycan was significantly decreased ( p < 0.05 ) in patients compared with that in healthy volunteers
Yasui et al., Biochem Biophys Res Commun 2007 (Hypersensitivity...) : HO-1 inhibited anti-OA serum/OA induced IL-3 and TNF-alpha production ... Inhibition of HO-1 activity by Zn ( II ) protoporphyrin IX, a specific HO-1 inhibitor, prevented the suppression of TNF-alpha production
Kirino et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : TNFalpha suppressed HO-1 expression by accelerating the decay of mRNA without affecting gene transcription or protein stability ... TNF antagonists may block this TNF dependent suppression of HO-1 expression, resulting in an amelioration of inflammation
Asija et al., Antioxid Redox Signal 2007 (Hyperglycemia) : The effects of HO-1 transduction ( Ad-VECAD-HO-1 gene ) on HO-1 expression, HO activity, and the response to TNF and hyperglycemia were studied ... Selective expression of HO-1 prevented TNF- and hyperglycemia mediated superoxide ( O2- ) formation, DNA degeneration, and upregulation of caspase, but increased the expression of pAkt and Bcl-xL, proteins responsible for endothelial dysfunction in diabetes
Rushworth et al., Blood 2008 (Leukemia, Myeloid, Acute...) : Further investigation revealed that the cytoprotective gene heme oxygenase-1 (HO-1) was induced in NF-kappaB inhibited AML cells in response to TNF stimulation, and HO-1 was responsible for the resistance of AML cells to the cytotoxic actions of TNF
Pae et al., Inflamm Res 2007 : Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
Gong et al., Int Immunopharmacol 2008 (Respiratory Distress Syndrome, Adult) : Heme oxygenase-1 upregulation significantly inhibits TNF-alpha and Hmgb1 releasing and attenuates lipopolysaccharide induced acute lung injury in mice
Rushworth et al., J Immunol 2008 (Inflammation...) : Additionally, overexpression of NQO1 and/or HO-1 inhibited LPS induced TNF and IL-1beta expression
Boost et al., Int J Mol Med 2009 : We demonstrated inhibition of TNF-alpha induced gene expression and release of IL-8 and HO-1 in human monocytic THP-1 cells exposed to both volatile anesthetics
Peterson et al., Cardiol Rev 2009 (Cardiovascular Diseases...) : HO-1 induction by pharmacological agents or the in vitro gene transfer of human HO-1 into ECs increases cell cycle progression and attenuates angiotensin II, tumor necrosis factor-alpha , and heme mediated DNA damage ; administration in vivo corrects blood pressure elevation after angiotensin II exposure
Lee et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : We examined our hypothesis whether inhibitory effects of aprotinin on cytokine induced inducible nitric oxide synthase (iNOS) expression ( IL-1beta plus TNF-alpha ), reactive oxygen species ( ROS ) generation, and vascular smooth muscle cell ( VSMC ) proliferation were due to HO-1 induction in rat VSMCs. Aprotinin induced HO-1 protein expression in a dose dependent manner, which was potentiated during inflammatory condition
Mandal et al., Hepatology 2010 : Inhibition of HO-1 activity, either by treatment with the HO-1 inhibitor zinc protoporphyrin or by siRNA knockdown of HO-1, prevented the inhibitory effect of gAcrp on LPS stimulated TNF-alpha expression in Kupffer cells
Yu et al., J Agric Food Chem 2010 : Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells
Rushworth et al., Oncotarget 2010 (Leukemia, Myeloid, Acute) : Here we show for the first time that the modulatory protein, FLICE-inhibitory protein (FLIP) indirectly regulates induction of HO-1 in response to TNF in human AML blasts, but not non-cancerous control cells
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1, MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Burgess et al., Cell Physiol Biochem 2012 : Up-regulation of HO-1 resulted in decreased MSC derived adipocyte differentiation, decreased production of TNF-alpha and MCP-1 and increased levels of adiponectin ( p < 0.05 )
Luz et al., J Immunol 2012 (Leishmaniasis, Visceral) : Furthermore, upregulation of HO-1 by cobalt protoporphyrin IX diminished the production of TNF-a and reactive oxygen species by infected murine macrophages and increased Cu/Zn superoxide dismutase expression in human monocytes
Lee et al., J Agric Food Chem 2013 (Diabetes Mellitus, Type 2) : It was found that monascin promoted heme oxygenase-1 (HO-1) expression mediated by Nrf2. Suppressions of AGEs, tumor necrosis factor-a (TNF-a), and interleukin-1ß ( IL-ß ) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid ( RA )
Kim et al., Shock 2013 (Reperfusion Injury) : Our findings suggest that the cytoprotective effects of HO-1 are mediated by suppression of TNF/TNFR1 mediated apoptotic signaling, specifically by modulating apoptotic DISC formation and mitochondrial TNFR1 translocation during hepatic I/R
Collino et al., Dis Model Mech 2013 (Disease Models, Animal...) : Besides, chronic HO-1 activation suppressed the elevated levels of myeloperoxidase (MPO) activity, interleukin 1ß (IL-1ß) production and tumor necrosis factor-a (TNFa) production that were evoked by the ischemic injury, and increased the plasma level of the anti-inflammatory cytokine IL-10
Terry et al., Am J Physiol 1998 (Inflammation) : Effect of tumor necrosis factor-alpha and interleukin-1 alpha on heme oxygenase-1 expression in human endothelial cells