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CASP12 — HPR

Text-mined interactions from Literome

Suzuki et al., Oncogene 1999 (Carcinoma, Squamous Cell...) : 4HPR induced cytochrome c release from mitochondria to cytoplasm, activated caspase-3 , and caused a membrane permeability transition ( MPT )
Shimada et al., Mol Carcinog 2002 (MAP Kinase Signaling System...) : We found that NFkappaB activation inhibited c-jun NH ( 2 ) -terminal kinase and caspase 3 activation induced by 4-HPR and that NFkappaB inhibition by the I kappa B alpha phosphorylation inhibitor compound Bay 117082 resulted in increasing sensitization of both PC-3 and DU145 lines to apoptosis induced by 4-HPR at low concentrations
Kim et al., Oncogene 2006 (Carcinoma, Squamous Cell...) : 4HPR increased ROS level within 1 h and induced activation of caspase 3 and PARP cleavage within 24 h. Activation of MKK3/6 and MKK4, JNK, p38 and ERK was detected between 6 and 12 h, increased up to 24 h and preceded apoptosis
Villani et al., Cancer Res 2006 (Breast Neoplasms...) : Apoptosis was induced by 4-oxo-4-HPR in both 4-HPR-sensitive and 4-HPR-resistant cells and involved activation of caspase-3 and caspase-9 but not caspase-8
Woo et al., Cancer Lett 2009 (Glioblastoma) : Stable ARF4 transfectants were also refractory to 4-HPR induced mitochondrial translocation of Bax, release of mitochondrial cytochrome c, and activation of caspase-3
Raguénez et al., BMC cancer 2009 (Neoplasm Metastasis...) : These results demonstrate that 4-HPR in up-regulating caspase-8 expression, restores and induces apoptotic cell death in metastatic neuroblasts through caspase-8 activation