Gene interactions and pathways from curated databases and text-mining

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IFNG — PRKAR2A

Text-mined interactions from Literome

Osna et al., Int Immunopharmacol 2001 : PKA played a role in the inhibition of IFN gamma by histamine when the cells were activated via TCR, and the PKA inhibitors Rp-cAMPS ( 10 ( -5 ) M ) and H8 ( 10 ( -5 ) M ) reversed the inhibitory effects of histamine on IFN gamma production ... However, when the cells were stimulated with ionomycin, the PKA inhibitors did not affect histamine mediated suppression of IFN gamma production
Cochrane et al., J Interferon Cytokine Res 2001 : In contrast, inhibitors of PKA or NOS, but not catalase, prevented FSK induced suppression of IFN-gamma production
Williams et al., J Immunol 2002 : Disruption of the AKAP-PKA interaction caused high levels of IL-2, IL-4, IL-5, and IFN-gamma production in the absence of stimulation via CD3epsilon and CD28 molecules
Liu et al., J Interferon Cytokine Res 2004 : Experimental data indicate that exogenous IFN-gamma stimulated cAMP accumulation and PKA activation in time dependent and dose dependent manners in murine peritoneal macrophages ... Moreover, IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly attenuated by PKA inhibition with H89
Hughes-Fulford et al., Cell Signal 2005 : Gene expression of IL-2R ( alpha ) and IFN(gamma) was dependent on PKA in S49 wt cells but not in kin- mutants ... Taken together, these results suggest that the PKA in addition to PKC and MAPK pathways plays a role in early T-cell activation and induction of IL-2, IL-2R ( alpha ) and IFN(gamma) gene expression
Bakhiet et al., Eur J Immunol 1993 : Although both the PKC and the PKA inhibitors suppressed PHA induced IFN-gamma secretion and proliferation of rat MNC and mouse CD8+ CD4- MNC, they had no effect on the same TLTF induced responses