Gene interactions and pathways from curated databases and text-mining

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IGFBP2 — IL6

Text-mined interactions from Literome

Feliers et al., Br J Haematol 1999 (Multiple Myeloma) : In contrast, IGFBP4 was not regulated in response to IL-6 , TNF-alpha, PDGF BB, bFGF, TGF-beta or the cAMP agonist, forskolin
Street et al., J Endocrinol 2003 : On day 4, IL-1beta ( 1 ng/ml ) and IL-6 ( 10 and 50 ng/ml ) reduced IGFBP-2 by 29+/-8 %, and by 32+/-9 and 38+/-8 % respectively ( P < 0.05 ) ... Both IGFBP-2 and IGFBP-4 were reduced by IL-1beta and IL-6 in combination at 1 and 10 ng/ml ( P < 0.05 ) ... IL-1beta and IL-6 in combination at 1 and 10 ng/ml reduced both IGFBP-2 and IGFBP-4.In conclusion, IGFBP-2 and IGFBP-4 secretion in CM decreased with Caco-2 cell differentiation