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IL4 — NOS2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Paludan et al., Scand J Immunol 1999
(Herpes Simplex) :
Our findings could indicate that
IL-4 suppresses IFN-gamma stimulated
iNOS transcription by elevating the level of IRF-2 which, through competition, prevents IRF-1 from binding to ISRE in the iNOS promoter
Heitmeier et al., J Biol Chem 1999
(Insulinoma) :
Prolonged STAT1 activation is associated with interferon-gamma priming for
interleukin-1 induced inducible
nitric-oxide synthase expression by islets of Langerhans
Coccia et al., Int Immunol 2000
:
IFN-gamma and
IL-4 differently
regulate inducible NO synthase gene expression through IRF-1 modulation ... Unidirectional deletion analysis on iNOS promoter demonstrated that an IFN stimulated responsive element ( ISRE ), contained in the -980 to -765 bp region of the iNOS promoter, may be involved in the
IL-4 mediated inhibition of IFN-gamma-inducible
iNOS transcription
Kitamura et al., Eur J Pharmacol 2001
:
These results suggest that the response to lipopolysaccharide is partially dependent on Toll-like receptor-4 in mouse glial cells, and that 15-deoxy-Delta ( 12,14 ) prostaglandin J ( 2 ) and
interleukin-4 differently
regulate the expression of
inducible NO synthase and cyclooxygenase-2, and heme oxygenase-1
Arriero et al., Surgery 2001
(Cholestasis) :
Recent data have suggested that
IL-4 attenuates
iNOS protein expression
Nédélec et al., Biochem Pharmacol 2001
:
In monolayers,
interleukin-1beta (IL-1beta)
induced COX-2 and
NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Snekvik et al., Vet Immunol Immunopathol 2001
:
Transcription of IL-4 mRNA was confirmed by transfection of COS-7 and goat synovial membrane cells, and recombinant
IL-4 produced by stably transfected L929 cells
inhibited inducible
nitric oxide synthase in macrophages
Knuefermann et al., Circulation 2002
(Inflammation...) :
Myocardial tumor necrosis factor,
interleukin-1beta (IL-1beta), and
NOS2 induction was measured before and 6 hours after LPS challenge
Xiong et al., J Biol Chem 2003
:
In addition,
interleukin-4 inhibits IFN-gamma induced
iNOS gene expression by attenuating the physical interaction of ICSBP with IRF-1
Levesque et al., Leukemia 2003
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
IL-4 and interferon gamma
regulate expression of inducible
nitric oxide synthase in chronic lymphocytic leukemia cells ...
IL-4 and IFN-gamma
increased B-CLL cell
NOS2 enzyme activity and protein expression during in vitro culture ... IFN-gamma, but not
IL-4 ,
increased NOS2 mRNA expression in cultured B-CLL cells suggesting that IL-4 mediated changes of NOS2 protein expression occurred at the post-transcriptional level ... In summary, we found that B-CLL cells expressed
NOS2 and that
IL-4 and IFN-gamma
increased B-CLL NOS2 expression
Miljkovic et al., Cell Mol Life Sci 2003
:
The
role of
interleukin-17 in inducible
nitric oxide synthase mediated nitric oxide production in endothelial cells
Cattaruzza et al., J Biol Chem 2003
:
Interleukin-10 induction of
nitric-oxide synthase expression
attenuates CD40 mediated
interleukin-12 synthesis in human endothelial cells
Miljkovic et al., Cytokine Growth Factor Rev 2004
(Inflammation...) :
Inducible
nitric oxide synthase activation by
interleukin-17
Lee et al., Exp Cell Res 2004
(Bone Resorption) :
In this study, we found that TNF-alpha, but not receptor activator of nuclear factor kappa B ligand and
interleukin 1,
increased the expression of
iNOS both at the mRNA and protein levels
Davis et al., Alcohol 2004
:
Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that
induction of
iNOS activity by tumor necrosis factor-alpha + interferon-gamma
+ interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration ( 200 mM ), but enhanced by 50 mM ethanol
Paoliello-Paschoalato et al., Cytokine 2005
:
Interleukin 4 induces the expression of inducible
nitric oxide synthase in eosinophils
Levesque et al., Leuk Res 2006
(Leukemia, Lymphocytic, Chronic, B-Cell) :
IL-4 and IFN-gamma
regulate B cell CD38 expression and
NOS2 expression
Linehan et al., Free Radic Biol Med 2005
(Colitis, Ulcerative...) :
IL-10 and
IL-4 but not IL-13
suppressed the NO production and
iNOS expression by inflamed tissue and cytokine stimulated noninflamed tissue from patients with ulcerative colitis, whereas the three cytokines suppressed NO production in cytokine stimulated biopsies from controls
Paintlia et al., J Immunol 2006
(Demyelinating Diseases...) :
In this study we demonstrate
IL-4 induced down-regulation of
inducible NO synthase (iNOS) expression and survival of differentiating oligodendrocyte progenitors ( OPs ) in proinflammatory cytokine ( Cyt-Mix ) -treated CNS glial cells, which is a condition similar to that observed in the brain of a patient with MS. IL-4 treatment of Cyt-Mix treated CNS glial cells significantly decreased iNOS expression/NO release with a parallel increase in survival of differentiating OPs
Zheng et al., J Biol Chem 2006
(Bone Resorption) :
Using murine RAW 264.7 and primary bone marrow cells or osteoclasts formed from them by receptor activator of NF-kappaB ligand ( RANKL ) differentiation, we found that
inducible nitric-oxide synthase (iNOS) expression and NO generation were
stimulated by interferon (IFN)-gamma or lipopolysaccharide, but not by
interleukin-1 or tumor necrosis factor-alpha
Lotz et al., Immunology 2007
:
Also,
IL-4 or IL-13 led to rapid signal transducer and activator of transcription 6 phosphorylation,
diminished inducible NO synthase expression, and enhanced the antagonistic arginase 1 activity
Morris et al., Tuberculosis (Edinb) 2009
:
Herein, we show that
IL-4 inhibited
iNOS gene expression at the transcriptional level, suggesting an inhibitory mechanism that is independent of the competition for l-arginine between iNOS and arginase
Yao et al., Inflamm Res 2010
:
Moreover, NF-kappaB p50, COX-2, and
iNOS levels in SF were markedly
suppressed by
AD-IL-18BP/IL-4 ...
AD-IL-18BP/IL-4 can
suppress the production and expression of inflammatory cytokines such as COX-2,
iNOS , and NF-kappaB in LPS stimulated SF
Macedo et al., Inflammation 2012
(Cystitis...) :
Exogenous
IL-4 also
attenuated TNF-a, IL-1ß,
iNOS , and COX-2 expressions in ifosfamide treated bladders
Xu et al., Biochem Biophys Res Commun 2011
(Cardiovascular Diseases...) :
Knock-down of RSK1 selectively down regulated
interleukin-1ß induced
iNOS expression without influencing VCAM-1 expression
Cho et al., J Nutr Biochem 2012
:
Effects of physiological quercetin metabolites on
interleukin-1ß induced
inducible NOS expression
Seo et al., Immunopharmacol Immunotoxicol 2012
(Inflammation) :
SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ),
interleukin-6 , and tumor necrosis factor-a and
inhibited the expression of
iNOS and COX-2 via attenuation of NF-?B p65 expression
Singh et al., J Biol Chem 1995
:
In vitro,
interleukin-1 beta and interferon-gamma
increased osteopontin mRNA levels in CMEC as well as
NOS2 expression in both CMEC and cardiac myocytes
Szabó et al., Eur J Pharmacol 1993
:
We investigated the
role of
interleukin-1 in the induction of a Ca ( 2+ ) -independent
nitric oxide ( NO ) synthase by bacterial endotoxin in vivo
Tetsuka et al., Proc Natl Acad Sci U S A 1994
:
Cross-talk between cyclooxygenase and nitric oxide pathways : prostaglandin E2 negatively modulates
induction of
nitric oxide synthase by
interleukin 1
Kanno et al., Hypertension 1993
:
Induction of
nitric oxide synthase gene by
interleukin in vascular smooth muscle cells
Melillo et al., J Immunol 1996
(Anoxia) :
Experiments in which ANA-1 macrophages were transfected transiently with the full-length iNOS promoter linked to a chloramphenicol acetyltransferase reporter gene demonstrated that
IL-4 also
down-regulated the IFN-gamma plus hypoxia induced activation of the
iNOS promoter
Liu et al., J Immunol 1996
:
In cytokine treated human astrocytes, neither
NOS II mRNA/protein expression nor nitrite production was
inhibited by TGF-beta,
IL-4 , or IL-10
Flak et al., Am J Respir Crit Care Med 1996
(Asthma...) :
The induction of
iNOS is most likely
due to the cytokine
interleukin-1 , which is generated intracellularly in response to TCT ; this cytokine, like TCT, can reproduce the pathology caused by B. pertussis infection
Heitmeier et al., J Biol Chem 1997
:
Interferon-gamma increases the sensitivity of islets of Langerhans for inducible
nitric-oxide synthase expression
induced by
interleukin 1
Guo et al., J Clin Invest 1997
:
Interferon gamma and
interleukin 4 stimulate prolonged expression of inducible
nitric oxide synthase in human airway epithelium through synthesis of soluble mediators ...
IFNgamma/IL-4- induced
iNOS expression in HAEC was delayed in onset and prolonged with expression up to 1 wk. Removal of overlying culture media resulted in loss of expression, while transfer of conditioned media induced iNOS mRNA in other HAEC
Benbernou et al., Immunology 1997
:
The generation of nitric oxide using sodium nitroprusside ( SNP ) induced a dramatic decrease of IFN-gamma, while IL-10 was enhanced ; and conversely the inhibition of
iNOS activity using 1-NG-monomethyl arginine ( 1-NMMA )
induced a clear inhibition of IL-10 and
IL-4 , while IFN-gamma was enhanced
Jungi et al., Clin Exp Immunol 1997
:
Antagonistic
effects of
IL-4 and interferon-gamma (IFN-gamma) on inducible
nitric oxide synthase expression in bovine macrophages exposed to gram positive bacteria
Kinugawa et al., Circ Res 1997
:
Forskolin,
interleukin (IL)-6 , tumor necrosis factor (TNF)-alpha, or interferon (IFN)-gamma
enhanced the LPS induced
iNOS expression
Guo et al., Environ Health Perspect 1998
:
The
IFN-gamma/IL-4 induced
iNOS expression in HAEC was delayed in onset and prolonged with expression up to 1 week ... Thus,
IFN-gamma/IL-4 , which occurs in human lung lining fluid,
led to
iNOS expression in human airway epithelium through production of soluble mediators and stabilization of mRNA
Chan et al., Biochem Biophys Res Commun 1998
:
The discordance between the marked degree of inhibition of iNOS transcript by IL-4 and the modest inhibition of JNK/SAPK and ERK suggests that the mechanism by which
IL-4 inhibits
iNOS transcription appears more complex than a mere inhibition of these MAPKs