Gene interactions and pathways from curated databases and text-mining

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IL4 — NOS2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Paludan et al., Scand J Immunol 1999 (Herpes Simplex) : Our findings could indicate that IL-4 suppresses IFN-gamma stimulated iNOS transcription by elevating the level of IRF-2 which, through competition, prevents IRF-1 from binding to ISRE in the iNOS promoter
Heitmeier et al., J Biol Chem 1999 (Insulinoma) : Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1 induced inducible nitric-oxide synthase expression by islets of Langerhans
Coccia et al., Int Immunol 2000 : IFN-gamma and IL-4 differently regulate inducible NO synthase gene expression through IRF-1 modulation ... Unidirectional deletion analysis on iNOS promoter demonstrated that an IFN stimulated responsive element ( ISRE ), contained in the -980 to -765 bp region of the iNOS promoter, may be involved in the IL-4 mediated inhibition of IFN-gamma-inducible iNOS transcription
Kitamura et al., Eur J Pharmacol 2001 : These results suggest that the response to lipopolysaccharide is partially dependent on Toll-like receptor-4 in mouse glial cells, and that 15-deoxy-Delta ( 12,14 ) prostaglandin J ( 2 ) and interleukin-4 differently regulate the expression of inducible NO synthase and cyclooxygenase-2, and heme oxygenase-1
Arriero et al., Surgery 2001 (Cholestasis) : Recent data have suggested that IL-4 attenuates iNOS protein expression
Nédélec et al., Biochem Pharmacol 2001 : In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Snekvik et al., Vet Immunol Immunopathol 2001 : Transcription of IL-4 mRNA was confirmed by transfection of COS-7 and goat synovial membrane cells, and recombinant IL-4 produced by stably transfected L929 cells inhibited inducible nitric oxide synthase in macrophages
Knuefermann et al., Circulation 2002 (Inflammation...) : Myocardial tumor necrosis factor, interleukin-1beta (IL-1beta), and NOS2 induction was measured before and 6 hours after LPS challenge
Xiong et al., J Biol Chem 2003 : In addition, interleukin-4 inhibits IFN-gamma induced iNOS gene expression by attenuating the physical interaction of ICSBP with IRF-1
Levesque et al., Leukemia 2003 (Leukemia, Lymphocytic, Chronic, B-Cell...) : IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells ... IL-4 and IFN-gamma increased B-CLL cell NOS2 enzyme activity and protein expression during in vitro culture ... IFN-gamma, but not IL-4 , increased NOS2 mRNA expression in cultured B-CLL cells suggesting that IL-4 mediated changes of NOS2 protein expression occurred at the post-transcriptional level ... In summary, we found that B-CLL cells expressed NOS2 and that IL-4 and IFN-gamma increased B-CLL NOS2 expression
Miljkovic et al., Cell Mol Life Sci 2003 : The role of interleukin-17 in inducible nitric oxide synthase mediated nitric oxide production in endothelial cells
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Miljkovic et al., Cytokine Growth Factor Rev 2004 (Inflammation...) : Inducible nitric oxide synthase activation by interleukin-17
Lee et al., Exp Cell Res 2004 (Bone Resorption) : In this study, we found that TNF-alpha, but not receptor activator of nuclear factor kappa B ligand and interleukin 1, increased the expression of iNOS both at the mRNA and protein levels
Davis et al., Alcohol 2004 : Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration ( 200 mM ), but enhanced by 50 mM ethanol
Paoliello-Paschoalato et al., Cytokine 2005 : Interleukin 4 induces the expression of inducible nitric oxide synthase in eosinophils
Levesque et al., Leuk Res 2006 (Leukemia, Lymphocytic, Chronic, B-Cell) : IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression
Linehan et al., Free Radic Biol Med 2005 (Colitis, Ulcerative...) : IL-10 and IL-4 but not IL-13 suppressed the NO production and iNOS expression by inflamed tissue and cytokine stimulated noninflamed tissue from patients with ulcerative colitis, whereas the three cytokines suppressed NO production in cytokine stimulated biopsies from controls
Paintlia et al., J Immunol 2006 (Demyelinating Diseases...) : In this study we demonstrate IL-4 induced down-regulation of inducible NO synthase (iNOS) expression and survival of differentiating oligodendrocyte progenitors ( OPs ) in proinflammatory cytokine ( Cyt-Mix ) -treated CNS glial cells, which is a condition similar to that observed in the brain of a patient with MS. IL-4 treatment of Cyt-Mix treated CNS glial cells significantly decreased iNOS expression/NO release with a parallel increase in survival of differentiating OPs
Zheng et al., J Biol Chem 2006 (Bone Resorption) : Using murine RAW 264.7 and primary bone marrow cells or osteoclasts formed from them by receptor activator of NF-kappaB ligand ( RANKL ) differentiation, we found that inducible nitric-oxide synthase (iNOS) expression and NO generation were stimulated by interferon (IFN)-gamma or lipopolysaccharide, but not by interleukin-1 or tumor necrosis factor-alpha
Lotz et al., Immunology 2007 : Also, IL-4 or IL-13 led to rapid signal transducer and activator of transcription 6 phosphorylation, diminished inducible NO synthase expression, and enhanced the antagonistic arginase 1 activity
Morris et al., Tuberculosis (Edinb) 2009 : Herein, we show that IL-4 inhibited iNOS gene expression at the transcriptional level, suggesting an inhibitory mechanism that is independent of the competition for l-arginine between iNOS and arginase
Yao et al., Inflamm Res 2010 : Moreover, NF-kappaB p50, COX-2, and iNOS levels in SF were markedly suppressed by AD-IL-18BP/IL-4 ... AD-IL-18BP/IL-4 can suppress the production and expression of inflammatory cytokines such as COX-2, iNOS , and NF-kappaB in LPS stimulated SF
Macedo et al., Inflammation 2012 (Cystitis...) : Exogenous IL-4 also attenuated TNF-a, IL-1ß, iNOS , and COX-2 expressions in ifosfamide treated bladders
Xu et al., Biochem Biophys Res Commun 2011 (Cardiovascular Diseases...) : Knock-down of RSK1 selectively down regulated interleukin-1ß induced iNOS expression without influencing VCAM-1 expression
Cho et al., J Nutr Biochem 2012 : Effects of physiological quercetin metabolites on interleukin-1ß induced inducible NOS expression
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes
Szabó et al., Eur J Pharmacol 1993 : We investigated the role of interleukin-1 in the induction of a Ca ( 2+ ) -independent nitric oxide ( NO ) synthase by bacterial endotoxin in vivo
Tetsuka et al., Proc Natl Acad Sci U S A 1994 : Cross-talk between cyclooxygenase and nitric oxide pathways : prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1
Kanno et al., Hypertension 1993 : Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells
Melillo et al., J Immunol 1996 (Anoxia) : Experiments in which ANA-1 macrophages were transfected transiently with the full-length iNOS promoter linked to a chloramphenicol acetyltransferase reporter gene demonstrated that IL-4 also down-regulated the IFN-gamma plus hypoxia induced activation of the iNOS promoter
Liu et al., J Immunol 1996 : In cytokine treated human astrocytes, neither NOS II mRNA/protein expression nor nitrite production was inhibited by TGF-beta, IL-4 , or IL-10
Flak et al., Am J Respir Crit Care Med 1996 (Asthma...) : The induction of iNOS is most likely due to the cytokine interleukin-1 , which is generated intracellularly in response to TCT ; this cytokine, like TCT, can reproduce the pathology caused by B. pertussis infection
Heitmeier et al., J Biol Chem 1997 : Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1
Guo et al., J Clin Invest 1997 : Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators ... IFNgamma/IL-4- induced iNOS expression in HAEC was delayed in onset and prolonged with expression up to 1 wk. Removal of overlying culture media resulted in loss of expression, while transfer of conditioned media induced iNOS mRNA in other HAEC
Benbernou et al., Immunology 1997 : The generation of nitric oxide using sodium nitroprusside ( SNP ) induced a dramatic decrease of IFN-gamma, while IL-10 was enhanced ; and conversely the inhibition of iNOS activity using 1-NG-monomethyl arginine ( 1-NMMA ) induced a clear inhibition of IL-10 and IL-4 , while IFN-gamma was enhanced
Jungi et al., Clin Exp Immunol 1997 : Antagonistic effects of IL-4 and interferon-gamma (IFN-gamma) on inducible nitric oxide synthase expression in bovine macrophages exposed to gram positive bacteria
Kinugawa et al., Circ Res 1997 : Forskolin, interleukin (IL)-6 , tumor necrosis factor (TNF)-alpha, or interferon (IFN)-gamma enhanced the LPS induced iNOS expression
Guo et al., Environ Health Perspect 1998 : The IFN-gamma/IL-4 induced iNOS expression in HAEC was delayed in onset and prolonged with expression up to 1 week ... Thus, IFN-gamma/IL-4 , which occurs in human lung lining fluid, led to iNOS expression in human airway epithelium through production of soluble mediators and stabilization of mRNA
Chan et al., Biochem Biophys Res Commun 1998 : The discordance between the marked degree of inhibition of iNOS transcript by IL-4 and the modest inhibition of JNK/SAPK and ERK suggests that the mechanism by which IL-4 inhibits iNOS transcription appears more complex than a mere inhibition of these MAPKs