Gene interactions and pathways from curated databases and text-mining

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CASP16 — IRF1

Text-mined interactions from Literome

Sancéau et al., Oncogene 2000 (Sarcoma, Ewing) : IFN-beta induces serine phosphorylation of Stat-1 in Ewing 's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7
Fantuzzi et al., Eur J Immunol 2001 : In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP ... In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Fulda et al., Oncogene 2002 (Neoplasms) : Moreover, ectopic expression of IRF1 induced caspase-8 expression thereby sensitizing cells for TRAIL-, APO1- or doxorubicin induced apoptosis
Detjen et al., Int J Oncol 2002 (Carcinoma, Neuroendocrine...) : Taken together our results characterize IFN-gamma as a potent proapoptotic stimulus in a subset of gastrointestinal NETs and suggest an IRF-1 mediated induction of caspase-1 as a relevant underlying mechanism
Suk et al., J Pharmacol Exp Ther 2003 : Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting caspase-11 activation, interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation ... Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting caspase-11 activation, interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation
Ruiz-Ruiz et al., J Biol Chem 2004 (Breast Neoplasms) : The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1
Bowie et al., Oncogene 2004 : Treatment of acutely damaged HMEC-E6 cells with 1.0 microM Tam resulted in recruitment of CBP to the gamma-IFN activated sequence element of the IRF-1 promoter, induction of IRF-1 , and sequential activation of caspase-1 and -3
De Ambrosis et al., Int J Cancer 2007 (Neuroblastoma) : Moreover, RNA interference experiments also supported the involvement of IRF-1 and IRF-2 in constitutive caspase-8 expression in NB cells
Stang et al., Oncogene 2007 (Breast Neoplasms) : Here we demonstrate that in MDA468 breast cancer cells, apoptosis by IFN-gamma is mediated by IRF-1 and IFN-gamma, and IRF-1 induced apoptosis is caspase mediated ... IRF-1 induction results in cleavage of caspase-8 , -3 and -7, and application of caspase inhibitors attenuate activated cleavage products
Liu et al., J Biol Chem 2012 (Disease Models, Animal...) : Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1 dependent caspase 8 activation ... Meanwhile, overexpression or knockdown of IRF-1 not only enhanced or inhibited GMC apoptosis and caspase 8 and 3 induction but also increased or decreased caspase 8 promoter activity, respectively