Gene interactions and pathways from curated databases and text-mining

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CREB5 — IRF6

Text-mined interactions from Literome

Kim et al., Brain Res 2000 (Glioma) : LPS transiently increased the phosphorylation of p38-MAPK and CREB ... Furthermore, LPS plus CHX enhanced phosphorylation of ERK, p38, and CREB in a synergistic manner
Cho et al., Glia 2001 : On the other hand, NAMDA increased intracellular cAMP levels and potentiated LPS induced phosphorylated cAMP-responsive element binding protein ( pCREB ) expression
Buzas et al., Glia 2002 : We observed CREB phosphorylation in response to LPS , which was also prevented by SB202190 and PD98059
Simi et al., J Neurochem 2005 : We found that ( 1 ) LPS induced c-fos mRNA levels were sensitive to p38 mitogen activated protein kinase ( MAPK ) inhibitors but not to mitogen-activated/extracellular signal regulated kinase ( ERK ) or calcium-calmodulin dependent kinase inhibitors, ( 2 ) LPS activated both serum response element ( SRE ) and cyclic AMP/calcium response element ( CRE ) -driven luciferase reporters in transient transfection assays, ( 3 ) LPS induced the phosphorylation of Elk1 CRE binding protein ( CREB ) /activated transcription factor-1 (ATF-1) and the activation of GAL4-Elk1 and GAL4-CREB chimeric proteins, and ( 4 ) mutation of both SRE and CRE elements was necessary and sufficient to completely abolish LPS induction of a rat c-fos proximal promoter-luciferase reporter
Sheu et al., Food Chem Toxicol 2006 (Glomerulonephritis) : Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein ( CREB ) induced by LPS/IFN-gamma
Woo et al., Immunobiology 2006 : Baicalein and baicalin had no effect on LPS induced nuclear factor-kappaB (NF-kappaB) and cAMP response element binding protein ( CREB ) DNA binding activity
Uto et al., Oncol Rep 2007 : LPS induced activation of all of these factors and 6-MITC suppressed LPS induced activation of AP-1, C/EBPdelta, CREB , but not NF-kappaB
Choi et al., Br J Pharmacol 2009 (MAP Kinase Signaling System) : In addition, the inhibitory effect of torilin on NF-kappaB and CREB was shown by torilin mediated recovery of LPS induced degradation of inhibitor kappaB-alpha and suppression of LPS induced phosphorylation of CREB respectively
Cho et al., Inflamm Res 2009 : Immunoblot, gel-shift, and chromatin-immunoprecipitation assays showed the activation of CREB by LPS , and the ability of H89 to inhibit it, suggesting that H89 's inhibition of CREB may affect MKP-1 induction
Dai et al., PloS one 2011 (MAP Kinase Signaling System) : In addition, gastrodin blocked LPS induced phosphorylation of inhibitor ?B-a ( I?B-a ) ( and hence the activation of NF-?B ) and of CREB , respectively
Moon et al., Exp Cell Res 2011 : cAMP production and CREB ( S133 ) phosphorylation were augmented by LPS-stimulation
Caruso et al., Mol Cell Endocrinol 2012 : Although both a-MSH and LPS+IFN-? increased cAMP responding element binding protein ( CREB ) activation, LPS+IFN-? did not modify BDNF expression