Gene interactions and pathways from curated databases and text-mining

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ITCH — WNT11

Text-mined interactions from Literome

Wei et al., Mol Cell Biol 2012 (Wnt Signaling Pathway) : The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein ... ITCH ubiquitinates the phosphorylated form of Dvl and promotes its degradation via the proteasome pathway, thereby inhibiting canonical Wnt signaling ... Consistently, overexpression of ITCH inhibited wild-type Dvl2 induced, but not Dvl2-Y568F mutant induced, Wnt reporter activity
Mössinger et al., EMBO Rep 2012 (Wnt Signaling Pathway) : Depletion of PI4KIIa or Itch regulates Wnt signalling with corresponding changes in Fz4 internalization and degradative sorting