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EGFR — ITGA5
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
EGFR
→
Complex of ITGA5-ITGB1
(increases, ITGA5/ITGB1 Activity, EGFR Activity)
Giancotti et al., Science 1999
Evidence: The receptors for insulin, plateletderived growth factor (PDGF), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are optimally activated by their ligands only under appropriate cell attachment conditions (24-28). Although a systematic analysis has not been conducted, certain integrins appear to be preferentially associated with specific growth factor receptors. Thus, the avb3 integrin can be immunoprecipitated in complexes with the insulin, PDGF, and VEGF receptors (...
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yoon et al., Cancer Res 2006
(Breast Neoplasms...) :
In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum depleted breast cancer cells
; integrin alpha(6)beta ( 4 )
regulates the expression of ErbB2 and the subsequent phosphorylation of
EGFR and activation of Ras
Wang et al., J Cell Physiol 2008
:
Integrin alpha5 induced
EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway
Chen et al., Mol Cell Biol 2010
:
Thus,
integrin alpha1beta1 negatively
regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1 dependent Cav-1 expression and consequent EGFR mediated ROS production