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AKT2 — JAK1

Text-mined interactions from Literome

Oki et al., Blood 2002 (Cell Transformation, Neoplastic) : These results suggest that Jak1 dependent Akt activation is important in v-Abl mediated transformation
Song et al., Chin J Cancer 2002 (Multiple Myeloma) : IL-6 inhibited apoptosis of XG-7 cells through up-regulation of Mcl-1 and the activation of JAK/STAT rather than Ras/MAPK nor PI-3K/Akt signal transduction pathway
Amaravadi et al., J Clin Invest 2005 (Inflammation...) : The PI3K dependent activation of the Akt kinases and the JAK/STAT dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways
Sharma et al., Endocr Relat Cancer 2006 (Endometrial Neoplasms...) : Moreover, leptin induced phosphorylation of ERK2 and AKT was dependent on JAK/STAT activation
El Mabrouk et al., Biochim Biophys Acta 2007 : Furthermore, JAK3 inhibition time-dependently down-regulated Akt but not ERK1/2 phosphorylation suggesting that Akt is a downstream target of JAK3
Saxena et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Leptin induced phosphorylation of ERK and AKT was dependent on Janus activated kinase ( JAK ) /STAT activation
Neilson et al., Mol Endocrinol 2007 (Breast Neoplasms) : Finally, suppression of Jak1 by lentiviral delivery of Jak1 short hairpin RNA blocked PRL activation of ERK and signal transducer and activator of transcription ( Stat ) 3 and suppressed PRL activation of Jak2, Stat5a, Stat5b, and Akt , as well as tyrosine phosphorylation of PRLR
Li et al., PloS one 2012 (Hypereosinophilic Syndrome) : Interestingly, JAK2 inhibition also reduced PI3K, Akt and NF-?B activity in a dose dependent manner, and suppressed expression levels of c-Myc and Survivin