Gene interactions and pathways from curated databases and text-mining

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AKT1 — KITLG

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: AKT1 → KITLG (increases) Arcaro et al., EMBO J 2002*
    Evidence: Stem cell factor (SCF) induced phosphorylation of PKB at Thr308 and Ser473 in H-69, H-209 and H-510 cells. Dominant negative form of PI3KC2B impaired SCF induced PKB activation.

Text-mined interactions from Literome

Uddin et al., Biochem Biophys Res Commun 2000 : Our results demonstrate that PKB/Akt is activated by Epo and SCF , but not by IGF-1 in human primary erythroid progenitors ... Our results demonstrate that PKB/Akt is activated by Epo and SCF , but not by IGF-1 in human primary erythroid progenitors
Endo et al., Exp Hematol 2001 : PP2 also inhibited SCF induced phosphorylation of Akt
Krystal et al., Mol Cancer Ther 2002 (Carcinoma, Small Cell...) : Both stem cell factor (SCF) and insulin-like growth factor (IGF)-I, components of prominent small cell lung cancer ( SCLC ) autocrine loops, as well as FCS, can potently activate phosphatidylinositol 3-kinase (PI3K)-Akt signaling, albeit with different kinetics ... SCF induced PI3K-Akt activation occurs rapidly but fades within 60 min ; IGF-I and FCS induced activation persists for at least 6 h. SCF and IGF-I mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling
Shivakrupa et al., Cell Signal 2005 : In this study, we used Lyn-deficient bone marrow mast cells ( BMMC ) to examine the contribution of this Src family member to tyrosine phosphorylation of Kit and SCF induced activation of Jnks, Akt , Stat3 and Erks
Reddy et al., Dev Biol 2005 : By using an in vitro oocytes culture system, we found that oocytes derived Akt and FKHRL1 are regulated by SCF
Arcaro et al., Cell Signal 2007 (Carcinoma, Small Cell) : Lipid raft integrity was essential for Src activation in response to stem cell factor (SCF) and raft disruption selectively inhibited activation of protein kinase B (PKB)/Akt in response to SCF stimulation ... Lipid raft integrity was essential for Src activation in response to stem cell factor (SCF) and raft disruption selectively inhibited activation of protein kinase B (PKB)/Akt in response to SCF stimulation
Quesada et al., Exp Neurol 2009 : MGF24 does not activate Akt signaling nor does Akt inhibition block MGF24 protection of SH-SY5Y cells
Li et al., Braz J Med Biol Res 2009 (Diabetes Mellitus, Experimental) : However, insulin or SCF could activate the phosphorylation of ERK1/2 and AKT in the diabetic cortex
Suyama et al., Oncol Rep 2010 (Lung Neoplasms...) : LY294002 and PD98059 inhibited SCF induced Akt and Erk activation in H209 cells, respectively ... If the SCF/c-kit contributes to Akt activation in vivo, the combination of STI571 and AMR may be effective against SCLC
Ciraolo et al., Mol Biol Cell 2010 (Azoospermia...) : In particular, p110beta is crucially needed in c-Kit mediated spermatogonial expansion, as c-Kit positive cells are lost in the adult testis and activation of Akt by SCF is blocked by a p110beta inhibitor
Shin et al., Exp Mol Med 2013 (Melanoma, Experimental) : Pretreatment of B16F10 cells with glyceollins dose-dependently inhibited SCF induced c-kit and Akt phosphorylation