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LCK — SLC22A3
Text-mined interactions from Literome
Gibson et al., J Immunol 1996
(Lymphoma, T-Cell) :
The EMT/ITK/TSK ( EMT ) tyrosine kinase is activated during TCR signaling :
LCK is
required for optimal activation of
EMT
Gibson et al., J Biol Chem 1996
:
Utilizing somatic cell mutants lacking LCK, we demonstrate that functional
LCK is
required for CD28 induced activation of
EMT as evidenced by increased tyrosine phosphorylation and kinase activity ... Furthermore, co-transfection of LCK and EMT into COS-7 cells showed that
EMT becomes phosphorylated in the
presence of
LCK ... The data are most compatible with a model in which
LCK , either directly or indirectly,
initiates EMT activation and association with CD28 following ligation of CD28
King et al., Int Immunol 1996
:
With the use of different Jurkat cell mutants it was demonstrated that CD2 mediated activation of
EMT required expression of
LCK , but not require surface expression of the CD3 zeta chain ... Receptor mediated activation of LCK does not in itself lead to activation of this Tec kinase since induction of
LCK by ligation of CD4 or CD5 did not
result in activation of
EMT
Lu et al., J Immunol 1998
:
Ligation of the TCR or CD28
induces activation of phosphatidylinositol 3-kinase (PI3K), the TEC family protein tyrosine kinase,
EMT/ITK/TSK ( EMT ) , and the SRC family tyrosine kinase,
LCK ...
LCK is
required for the activation and phosphorylation of
EMT induced by ligation of the TCR or CD28 placing LCK upstream of EMT in T cell signaling cascades ... In contrast, PI3K inhibitors did not alter CD28 or CD3 cross linking or
LCK induced
EMT phosphorylation ... CD28 induced association of
EMT with PI3K also
requires functional expression of
LCK