◀ Back to SLC22A3

LCK — SLC22A3

Text-mined interactions from Literome

Gibson et al., J Immunol 1996 (Lymphoma, T-Cell) : The EMT/ITK/TSK ( EMT ) tyrosine kinase is activated during TCR signaling : LCK is required for optimal activation of EMT
Gibson et al., J Biol Chem 1996 : Utilizing somatic cell mutants lacking LCK, we demonstrate that functional LCK is required for CD28 induced activation of EMT as evidenced by increased tyrosine phosphorylation and kinase activity ... Furthermore, co-transfection of LCK and EMT into COS-7 cells showed that EMT becomes phosphorylated in the presence of LCK ... The data are most compatible with a model in which LCK , either directly or indirectly, initiates EMT activation and association with CD28 following ligation of CD28
King et al., Int Immunol 1996 : With the use of different Jurkat cell mutants it was demonstrated that CD2 mediated activation of EMT required expression of LCK , but not require surface expression of the CD3 zeta chain ... Receptor mediated activation of LCK does not in itself lead to activation of this Tec kinase since induction of LCK by ligation of CD4 or CD5 did not result in activation of EMT
Lu et al., J Immunol 1998 : Ligation of the TCR or CD28 induces activation of phosphatidylinositol 3-kinase (PI3K), the TEC family protein tyrosine kinase, EMT/ITK/TSK ( EMT ) , and the SRC family tyrosine kinase, LCK ... LCK is required for the activation and phosphorylation of EMT induced by ligation of the TCR or CD28 placing LCK upstream of EMT in T cell signaling cascades ... In contrast, PI3K inhibitors did not alter CD28 or CD3 cross linking or LCK induced EMT phosphorylation ... CD28 induced association of EMT with PI3K also requires functional expression of LCK