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LOX — TNF

Text-mined interactions from Literome

Harada et al., Clin Exp Rheumatol 2003 (Arthritis, Rheumatoid) : Although interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) , major inflammatory cytokines in rheumatoid synovia, did not induce the expression of 15-LOX , IL-4 and these inflammatory cytokines synergistically enhanced the protein expression of 15-LOX
Pischon et al., J Biol Chem 2004 (Inflammation) : Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts ... The data together demonstrate that TNF-alpha does not inhibit collagen synthesis but does inhibit the expression and activity of lysyl oxidase in osteoblasts, thereby contributing to perturbed collagen cross linking and accumulation
Shibata et al., Atherosclerosis 2007 : Mulberry leaf aqueous fractions inhibit TNF-alpha induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1 ( LOX-1 ) expression in vascular endothelial cells
Rodríguez et al., Atherosclerosis 2008 : In transfection assays, TNFalpha reduced LOX transcriptional activity to a similar extent than LOX mRNA ... Moreover, while TNFR associated factor-2 (TRAF-2) did not mediate signalling events leading to LOX inhibition, PKC inhibitors counteracted the TNFalpha induced decrease of LOX mRNA levels
Alcudia et al., Frontiers in bioscience : a journal and virtual library 2008 (Cardiovascular Diseases...) : Interestingly, in vivo studies reveal that TNF-alpha causes a down-regulation of vascular LOX expression
Piao et al., Carcinogenesis 2008 (Cell Transformation, Neoplastic...) : The expression of p12-LOX was significantly higher in JB6 P+ cells than in JB6 P- cells that were resistant to transformation, and its expression was further increased by tumor necrosis factor (TNF)-alpha ... These results indicate that p12-LOX is induced by the inflammatory cytokine TNF-alpha in the early stage of tumorigenesis, and is required for tumor promotion through enhancing efficient proliferation of a small number of initiated cells
Zhang et al., Clin Sci (Lond) 2009 (Vascular Diseases) : AGEs ( advanced glycation end-products ) /RAGE ( receptor for AGEs ), LOX-1 [ lectin-like oxidized low-density lipoprotein receptor-1 ) and NF-kappaB ( nuclear factor kappaB ) signalling play key roles in TNF-alpha expression through an increase in circulating and/or local vascular TNF-alpha production
Lee et al., J Enzyme Inhib Med Chem 2010 : Curcumin inhibits TNFalpha induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells ( HUVECs ) by an antioxidant mechanism
Orita et al., J Orthop Sci 2012 (Disease Models, Animal...) : Lox suppressed TNF-a and NGF more than ket, whereas ket suppressed IL-6 more