Gene interactions and pathways from curated databases and text-mining

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HIF1A — MAP2K1

Text-mined interactions from Literome

Hellwig-Bürgel et al., Cell Physiol Biochem 2005 : The study shows that PI3K but not MAPKK-1 inhibition resulted in the loss of hypoxic and IL-1beta induced HIF-1alpha accumulation, whereas VEGF synthesis was reduced by either intervention
Luwor et al., Oncogene 2005 : Pharmacologic inhibition of phosphatidylinositol 3-kinase with LY294002 reduced the HIF-1alpha level in both normoxic and hypoxic A431 cells, whereas inhibition of the mitogen activated protein kinase kinase by PD98059 reduced the level of HIF-1alpha only in normoxic A431 cells