Gene interactions and pathways from curated databases and text-mining

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JUN — MAP2K6

Text-mined interactions from Literome

Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Naumann et al., J Biol Chem 1999 : The c-Jun activation caused by Sgn2 overexpression is independent of JNK and mitogen activated protein kinase kinase 4
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Andreone et al., J Immunol 2003 : In murine wild-type fibroblasts, oxidative challenge by peroxynitrite and hydrogen peroxide or immunological challenge by IL-1 and 20 % FCS induced phosphorylation of the mitogen activated protein kinase kinase-4 , activation of c-Jun N-terminal kinase (JNK) , and DNA binding of AP-1
Ryborg et al., Acta Derm Venereol 2004 : The effects on transglutaminase-1 and AP-1 were dependent on protein kinase C and mitogen activated protein kinase kinase
Lotan et al., Cancer Res 2008 (Neoplasm Metastasis...) : c-Jun NH2-terminal kinase activating kinase 1/mitogen activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation