Gene interactions and pathways from curated databases and text-mining

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CDH1 — MAPK9

Text-mined interactions from Literome

Reddy et al., Mol Endocrinol 2005 (MAP Kinase Signaling System...) : Akt activation is mediated through the activation of phosphatidylinositol 3 kinase, and both Akt and MAPK activation are mediated by an E-cadherin adhesion induced ligand independent activation of epidermal growth factor receptor
Huan et al., J Biol Chem 2005 (Carcinoma...) : Chromatin precipitation analyses and E-cadherin promoter reporter gene assays revealed that E-cadherin induction by TFE3 or TFEB was primarily or exclusively direct and mitogen activated protein kinase dependent in those cell types
Ordóñez-Morán et al., J Cell Biol 2008 (Colonic Neoplasms) : As shown by the use of chemical inhibitors, dominant negative mutants and small interfering RNA, RhoA-ROCK, and p38MAPK-MSK1 activation is necessary for the induction of CDH1/E-cadherin , CYP24, and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 ) ... As shown by the use of chemical inhibitors, dominant negative mutants and small interfering RNA, RhoA-ROCK, and p38MAPK-MSK1 activation is necessary for the induction of CDH1/E-cadherin , CYP24, and other genes and of an adhesive phenotype by 1,25 ( OH ) ( 2 ) D ( 3 )
Cheng et al., Mol Endocrinol 2010 (Ovarian Neoplasms) : Furthermore, the involvement of p38 MAPK in the down-regulation of E-cadherin was confirmed using specific p38alpha MAPK small interfering RNA
Kolosova et al., J Cell Physiol 2011 : However, neither Smad2/3 nor p38 MAPK were required for the down-regulation of E-cadherin , yet p38 MAPK was associated with fibronectin up-regulation ... However, neither Smad2/3 nor p38 MAPK were required for the down-regulation of E-cadherin , yet p38 MAPK was associated with fibronectin up-regulation
Tomlinson et al., PloS one 2012 : MAPK activation regulated migration and E-cadherin expression, indicating that combined activation of PLC? and MAPK is required for a full EMT
Lau et al., PloS one 2013 (Neoplasm Invasiveness...) : The pharmacological inhibition of phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), and MEK suggests that both PI3K/Akt/mTOR and MAPK/ERK signaling are required for FGF2 induced E-cadherin down-regulation