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AKT2 — MAPKAPK2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Taniyama et al., Am J Physiol Cell Physiol 2004
(MAP Kinase Signaling System) :
Role of p38 MAPK and
MAPKAPK-2 in angiotensin II-induced
Akt activation in vascular smooth muscle cells
Hu et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
Akt2 inhibition
blocked ezrin but not p38 MAPK or
MAPKAPK-2 phosphorylation, suggesting that MAPKAPK-2 could be an intermediate in p38 MAPK dependent Akt2 activation ... siRNA mediated
MAPKAPK-2 knockdown
inhibited phosphorylation of
Akt2 and ezrin but not p38 MAPK ... Thus,
MAP-KAPK-2 controls
Akt2 phosphorylation ... Thus,
MAP-KAPK-2 controls
Akt2 phosphorylation
Miller-Jensen et al., J Cell Sci 2006
:
Surprisingly, further activation of
Akt in Adv infected cells via insulin treatment did not significantly
reduce apoptosis or
MK2 activity
Zheng et al., J Biol Chem 2006
:
However,
MK2 is not
required for the association of hsp27 with
Akt
Wu et al., J Biol Chem 2007
:
Here we show that loss of
Akt/Hsp27 interaction by anti-Hsp27 antibody treatment
resulted in loss of
Akt/MK2 interaction, loss of Akt-Ser-473 phosphorylation, and induced PMN apoptosis ... Silencing Hsp27 expression inhibited
Akt/MK2 interaction,
inhibited Akt phosphorylation and
Akt activation, and induced HK-11 cell death