Gene interactions and pathways from curated databases and text-mining

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IRF6 — MARCKS

Text-mined interactions from Literome

Zhao et al., J Cell Biochem 2000 (Gram-Negative Bacterial Infections...) : Therefore, in the present study, we investigated LPS induced MARCKS phosphorylation in bovine pulmonary artery EC ( BPAEC ) ... LPS potentiated MARCKS phosphorylation in BPAEC in a time- and dose dependent manner ... The PKC inhibitor, calphostin C, significantly decreased LPS induced phosphorylation of MARCKS ... In addition, downregulation of PKC with phorbol 12-myristate 13-acetate ( PMA ) did not affect the LPS induced MARCKS phosphorylation, suggesting that LPS and PMA activate different isoforms of PKC ... Pretreatment with SB203580, a specific inhibitor of p38 MAP kinase, or genistein, a tyrosine kinase inhibitor, prevented LPS induced MARCKS phosphorylation ... LPS also enhanced both thrombin- and PMA induced phosphorylation of MARCKS , suggesting that LPS was able to prime these signaling pathways in BPAEC ... In conclusion, LPS stimulated MARCKS phosphorylation in BPAEC
Sunohara et al., J Neurochem 2001 : Pro-inflammatory cytokines produced by activated microglia ( IL-1beta, IL-6, TNF-alpha ) did not mimic LPS effects on MARCKS or MRP expression when added individually or in combination ... Induction of MARCKS and MRP by LPS was completely blocked by inhibitors of NF-kappaB ( PDTC ) and protein tyrosine kinases ( herbimycin A ), partially blocked by the p38 kinase inhibitor SB203580, and unaffected by the MEK inhibitor PD98059 ... The Src kinase inhibitor PP2 had no effect, while the closely related inhibitor PP1 actually increased LPS induction of MARCKS and MRP
Rosé et al., J Neurosci Res 1996 : TNF alpha and colony stimulating factor 1 (CSF-1), two cytokines which are induced by LPS, did not reproduce the observed effect of LPS on MARCKS and MRP gene transcription