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IRF6 — MARCKS
Text-mined interactions from Literome
Zhao et al., J Cell Biochem 2000
(Gram-Negative Bacterial Infections...) :
Therefore, in the present study, we investigated
LPS induced
MARCKS phosphorylation in bovine pulmonary artery EC ( BPAEC ) ...
LPS potentiated
MARCKS phosphorylation in BPAEC in a time- and dose dependent manner ... The PKC inhibitor, calphostin C, significantly decreased
LPS induced phosphorylation of
MARCKS ... In addition, downregulation of PKC with phorbol 12-myristate 13-acetate ( PMA ) did not affect the
LPS induced
MARCKS phosphorylation, suggesting that LPS and PMA activate different isoforms of PKC ... Pretreatment with SB203580, a specific inhibitor of p38 MAP kinase, or genistein, a tyrosine kinase inhibitor, prevented
LPS induced
MARCKS phosphorylation ...
LPS also
enhanced both thrombin- and PMA induced phosphorylation of
MARCKS , suggesting that LPS was able to prime these signaling pathways in BPAEC ... In conclusion,
LPS stimulated
MARCKS phosphorylation in BPAEC
Sunohara et al., J Neurochem 2001
:
Pro-inflammatory cytokines produced by activated microglia ( IL-1beta, IL-6, TNF-alpha ) did not mimic
LPS effects on
MARCKS or MRP expression when added individually or in combination ...
Induction of
MARCKS and MRP by
LPS was completely blocked by inhibitors of NF-kappaB ( PDTC ) and protein tyrosine kinases ( herbimycin A ), partially blocked by the p38 kinase inhibitor SB203580, and unaffected by the MEK inhibitor PD98059 ... The Src kinase inhibitor PP2 had no effect, while the closely related inhibitor PP1 actually increased
LPS induction of
MARCKS and MRP
Rosé et al., J Neurosci Res 1996
:
TNF alpha and colony stimulating factor 1 (CSF-1), two cytokines which are induced by LPS, did not reproduce the observed
effect of
LPS on
MARCKS and MRP gene transcription