◀ Back to IRF6
IRF6 — MIP
Text-mined interactions from Literome
Xavier et al., Am J Respir Cell Mol Biol 1999
:
LPS stimulation
induced a dose- and time dependent release of
MIP-2 ... The
LPS induced
MIP-2 production is regulated at both the transcriptional and post-transcriptional levels ... Polyclonal and monoclonal antibodies against TNF-alpha also attenuated
LPS induced
MIP-2
Mourgeon et al., Am J Physiol Lung Cell Mol Physiol 2000
:
At both the 1- and 4-h time points, only
LPS increased
MIP-2 mRNA levels
Isowa et al., Am J Physiol Lung Cell Mol Physiol 2001
:
A lower concentration ( 0.1 microM ) of CytoD inhibited
LPS induced
MIP-2 production without affecting microfilament polymerization ... In contrast,
LPS induced
MIP-2 production was enhanced by a higher concentration ( 10 microM ) of CytoD, which disrupted the filamentous structure of actin ... Jasplakinolide ( 1 nM to 1 microM ), a polymerizing agent for microfilaments, decreased
LPS induced
MIP-2 secretion ... These results suggest that, in alveolar epithelial cells,
LPS induced
MIP-2 production is at least partially regulated by microfilament depolymerization
Zhang et al., Shock 2002
(Pneumonia) :
Intratracheal
LPS induced a significant increase in
MIP-2 in bronchoalveolar lavage (BAL) fluid with no detectable MIP-2 in the plasma ... Intravenous
LPS caused a marked increase in plasma
MIP-2 and CINC, whereas only a small elevation of both MIP-2 and CINC concentrations in BAL fluid was observed
Wang et al., Inflammation 2002
(Bacterial Infections) :
CGRP ( 0.1 nM-10 nM ) partially reversed this decreased production of
LPS induced KC and
MIP-2 from peritoneal macrophages
Laudes et al., J Immunol 2002
:
Although
LPS or IFN-gamma alone
induced some release of MCP-1 and
MIP-2 , pre-exposure of these monolayers to LPS or IFN-gamma, followed by addition of C5a, resulted in synergistic production of MIP-2 and MCP-1
Rousseau et al., EMBO J 2002
:
The
LPS induced stabilization of MIP-2 mRNA and production of
MIP-2 protein were abolished when macrophages were incubated with SB 203580 plus PD 184352 ( which inhibits the classical MAP kinase cascade )
Zeidler et al., J Toxicol Environ Health 2003
:
LPS , but not silica,
induced TNF-á and
MIP-2 production in both iNOS KO and WT AMs ... In addition,
LPS induced TNF-á and
MIP-2 production tend to be higher in AMs from iNOS KO mice
Kim et al., Mol Immunol 2003
:
Transcription of the
MIP-2 gene is rapidly
induced by
lipopolysaccharide (LPS) stimulation in cells of macrophage lineage ... By deletion analysis of the MIP-2 promoter region, we show that NF-kappaB and c-Jun binding sites are essential for
LPS induced
MIP-2 gene expression
Tsujimoto et al., Shock 2005
(Disease Models, Animal...) :
LPS induced
MIP-2 production by bronchoalveolar cells and liver mononuclear cells in mice with peritonitis was also significantly increased compared with sham operated mice
Husted et al., J Surg Res 2005
:
The data show that delta2- but not delta1-opioid agonists suppress
LPS induced p38 MAPK activation and expression of TNFalpha and
MIP-2
Gueders et al., J Immunol 2005
(Respiratory Hypersensitivity) :
Although allergen exposure induced an enhancement of
LPS induced CXC chemokine, KC, and
MIP-2 levels in BALF and lung parenchyma, no difference was observed between the two genotypes
Jeyaseelan et al., J Immunol 2005
(Escherichia coli Infections...) :
LPS induced neutrophil sequestration ; NF-kappaB translocation ; keratinocyte cell derived chemokine,
MIP-2 , TNF-alpha, and IL-6 expression ; histopathology ; and VCAM-1 and ICAM-1 expression were abolished in the lungs of TIRAP-/- mice
Inoue et al., FASEB J 2006
(Inflammation...) :
In both genotypes of mice,
LPS enhanced protein expression of interleukin (IL)-1beta, IL-6, granulocyte/macrophage-colony stimulating factor,
macrophage inflammatory protein (MIP)-1alpha , MIP-2, macrophage chemoattractant protein-1, and keratinocyte chemoattractant in the lung, kidney, and liver and circulatory levels of IL-1beta, IL-6, MIP-2, and KC
Lin et al., J Leukoc Biol 2007
(Disease Models, Animal...) :
Cell types associated with corneal inflammation produced markedly different chemokines in vitro : Murine corneal fibroblasts ( MK/T-1 ) produced LIX and KC in
response to
LPS but did not produce
MIP-2 , whereas peritoneal macrophages and neutrophils produced MIP-2 and KC but did not produce LIX
Kim et al., Immunol Cell Biol 2007
:
However, 15d-PGJ ( 2 ) enhanced the expression of
LPS induced
MIP-2 ( CXCL2 ) mRNA ... Although the synergistic effect of 15d-PGJ ( 2 ) on
LPS induced
MIP-2 ( CXCL2 ) mRNA expression was remarkable, the production of MIP-2 ( CXCL2 ) in cells treated with 15d-PGJ ( 2 ) and LPS did not increase compared to the production in cells treated with LPS alone ... These results suggest that the synergistic effect of 15d-PGJ ( 2 ) on
LPS induced
MIP-2 ( CXCL2 ) expression is PPARgamma independent, and is mediated by the p38 and SAPK/JNK pathway in mitogen activated protein kinase signaling pathways, which activates NF-kappaB
Bi et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006
(Acute Lung Injury...) :
LPS markedly
induced an increase in leukocyte infiltration, W/D ratio, lung MPO activity, release of TNF-alpha as well as
MIP-2 into alveolar space in both lipids and NaCl groups
Fuse et al., J Med Microbiol 2007
(Disease Models, Animal...) :
Reduced
MIP-2 production was demonstrated in bone-marrow derived macrophages from TLR2-deficient mice in
response to live L. pneumophila and purified
LPS of this strain, but not Escherichia coli LPS
Porter et al., J Toxicol Environ Health 2007
:
Molecular studies confirmed that LPS stimulated NF-kappaB mRNA expression, and PGJ2 reduced this stimulation, which is consistent with PGJ2 effect on
LPS induced production of NO, TNF-alpha and
MIP-2
Bhavsar et al., Thorax 2008
(Asthma) :
The inhibition of
LPS induced interleukin (IL)1beta, IL6, IL8, monocyte chemotactic protein (MCP)-1 and
macrophage inflammatory protein (MIP)-1alpha release by dexamethasone ( 10 ( -6 ) M ) was significantly less in macrophages from patients with severe asthma than in macrophages from patients with non-severe asthma
Kim et al., Mol Cells 2008
:
In addition, rosmarinic acid reduced cell migration by inducing the expression of a specific chemokine receptor on LPS induced mature BMDCs. Rosmarinic acid also significantly reduced the expressions of MCP-1 and
MIP-lalpha induced by LPS in BMDCs and
inhibited LPS induced activation of MAPK and the nuclear translocation of NF-kappaB
Joo et al., PloS one 2009
(Colitis...) :
In vitro, TLE blocked
LPS induced IkappaBalpha degradation, RelA translocation, NF-kappaB transcriptional activity and
MIP-2 mRNA accumulation in IEC-18 cells
Chung et al., Mol Cells 2009
:
These results indicate that A. actinomycetemcomitans
LPS stimulates the several chemokines expressions ( MIP-1alpha, MIP-1beta, MIP-1gamma, RANTES,
MIP-2 , and IP 10 ) in Raw 264.7 cells
Hoth et al., J Trauma 2009
(Contusions...) :
Injury +
LPS showed immune priming observed by lung injury histology and
increased bronchoalveolar lavage neutrophilia, lung myeloperoxidase and serum IL-6, CXCL1, and
MIP-2 levels when compared with injury + vehicle or LPS alone
Ding et al., Inflamm Res 2010
:
A FQHPSFI peptide selectively binds to LPS activated alveolar macrophages and inhibits
LPS induced
MIP-2 production ... The identified FQHPSFI peptide may be used for the modulation of
LPS stimulated
MIP-2 production in AMs
Wu et al., Respir Res 2010
(Cystic Fibrosis...) :
Neither aspirin nor ATK interfered with
LPS induced airway neutrophil influx or
MIP-2 production
Larmonier et al., Inflamm Bowel Dis 2011
(Disease Models, Animal) :
Curcumin attenuated
lipopolysaccharide (LPS) stimulated expression and secretion of macrophage inflammatory protein (MIP)-2, interleukin (IL)-1ß, keratinocyte chemoattractant ( KC ), and
MIP-1a in colonic epithelial cells ( CECs ) and in macrophages
Peters et al., J Pharmacol Exp Ther 2010
(Disease Models, Animal...) :
However, neither PAR(2) activating peptides nor PGE ( 2 ) inhibited
LPS induced generation of
MIP-2 in cultures of primary murine alveolar macrophages In summary, PAR(2) activating peptides and PGE ( 2 ) suppressed LPS induced neutrophilia in murine airways, independently of an inhibitory action on MIP-2 generation by alveolar macrophages
Mencarelli et al., Eur J Pharmacol 2011
:
Finally, exposure of human colon biopsies from inflammatory bowel diseases patients to rifaximin reduced mRNA levels of IL-8, Rantes,
MIP-3a and TNFa
induced by
LPS
Li et al., Acta Pharmacol Sin 2011
(Endotoxemia) :
Furthermore,
LPS significantly
induced enterocyte apoptosis, increased TLR4 mRNA expression, I-?Ba phosphorylation,
MIP-2 production and myeloperoxidase content in the ileum
Standiford et al., Alcohol Clin Exp Res 1997
(Alcoholism) :
Two-week ethanol feeding resulted in substantial impairment in the
lipopolysaccharide (LPS) induced expression of TNF-alpha,
MIP-2 , and MIP-1 alpha mRNA, and protein from LPS stimulated AMs, compared with cytokine production from AMs obtained from CD-1 mice receiving an isocaloric control diet