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MPL — TNF

Text-mined interactions from Literome

Mouithys-Mickalad et al., Biochem Biophys Res Commun 2004 : HCT and MPL inhibited the production of the cytokines TNFalpha and IL-8
Okemoto et al., J Immunol 2006 : MPL enhanced the secretion of TNF-alpha , but not that of IL-1beta, whereas Escherichia coli-type lipid A ( natural source derived and chemically synthesized lipid A ) enhanced the secretion of both cytokines
Cao et al., J Med Food 2012 : Meanwhile, compared with the control group, not only the mRNA expressions of tumor necrosis factor-a (TNF-a) , interleukin-6 (IL-6), and interferon-? ( IFN-? ) in macrophages, but also the productions of proteins, were strongly induced by MPL ; these effects were inhibited by pyrrolidine dithiocarbamate
Vitoriano-Souza et al., PloS one 2012 : We also observed that MPL induced high production of IL-2, TNF-a , and IFN-?, in addition to IL-6, IL-17, and IL-10
Kiener et al., J Immunol 1988 (Shock, Septic) : These results suggest that the non-toxic MPL as well as the toxic forms of lipid A can induce the production of TNF by macrophages