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CTNNB1 — MYC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → CTNNB1 (decreases, MYC Activity)
  Evidence: we next investigated target genes of b-catenin, in particular, c-Jun, c-Myc, and cyclin D1, and their possible contribution to the anti-MM effect of enzastaurin. Our results show that b-catenin induces c-Jun, whereas c-Myc was markedly down-regulated #(this is protein - western blots in fig 3A)
• FastForward regulation: CTNNB1 → MYC (transcriptional regulation, increase) Ciznadija et al., Cell Death Differ 2009*
  Evidence: PROMACTIVITY, DNABINDING
• FastForward regulation: TCF4, CTNNB1 → MYC (transcriptional regulation, increase) Yochum et al., Proc Natl Acad Sci U S A 2010*
  Evidence: REG, DNABINDING
• FastForward regulation: TCF4, CTNNB1 → MYC (transcriptional regulation, increase) Yochum et al., J Biol Chem 2007*
  Evidence: REG, DNABINDING
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) → MYC (MYC) (transcription, activates) Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 complex (CTNNB1-HNF1A-CTBP1-CREBBP-TLE1-AES) → MYC (MYC) (transcription, activates)
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3) → MYC (MYC) (transcription, activates) Gan et al., J Cell Biol 2008
  Evidence: reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: Complex of CTNNB1-ESR1-EZH2-MYC (unknown, -) Shi et al., Mol Cell Biol 2007*
• IRef Innatedb Interaction: MYC — CTNNB1 (unknown, -) Dutta-Simmons et al., Blood 2009*
• IRef Innatedb Interaction: MYC — CTNNB1 (unknown, -) Lim et al., Cancer Res 2008*
• IRef Innatedb Interaction: MYC — CTNNB1 (unknown, -) Yan et al., J Biol Chem 2006*
• IRef Innatedb Interaction: MYC — CTNNB1 (unknown, -) Nateri et al., Nature 2005

Text-mined interactions from Literome

Jaiswal et al., Oncogene 2002 (Colonic Neoplasms) : We further investigated the association of the beta-catenin mediated c-Myc expression and the cell-cell adhesion pathways in curcumin induced G ( 2 ) /M arrest and apoptosis in HCT-116 cells
Saldanha et al., Br J Dermatol 2004 (Carcinoma, Basal Cell...) : In turn, nuclear beta-catenin can increase expression of MYC and cyclin D1, thus potentially altering proliferation
Ju et al., Cancer Res 2005 (Intestinal Neoplasms) : Treatment of HT29 human colon cancer cells with EGCG ( 12.5 or 20 micromol/L at different times ) also increased protein levels of E-cadherin by 27 % to 58 %, induced the translocation of beta-catenin from nucleus to cytoplasm and plasma membrane, and decreased c-Myc and cyclin D1 ( 20 micromol/L EGCG for 24 hours )
Noubissi et al., Nature 2006 : CRD-BP is essential for the induction of both betaTrCP1 and c-Myc by beta-catenin signalling in colorectal cancer cells
Li et al., Oncogene 2007 (Colonic Neoplasms) : As expected, beta-catenin induced its downstream target c-Myc , as well as E2F1 and Bcl-2, and this was blocked by siRNA to c-Myc or E2F1
Alves-Guerra et al., Cancer Res 2007 (Colonic Neoplasms) : Finally, we show that the knockdown of Mastermind-like family proteins in colonic carcinoma cells results in cell death by affecting beta-catenin induced expression of cyclin D1 and c-Myc
Momota et al., Oncogene 2008 (Disease Models, Animal...) : As elevated c-Myc expression, activation of Wnt/beta-catenin signaling and dysfunction of p53 are seen in human PNETs, we investigated what role these abnormalities have in the formation of PNETs
Palozza et al., Carcinogenesis 2008 (Colonic Neoplasms...) : Silencing of c-Myc attenuated beta-carotene induced apoptosis and beta-catenin expression
Ciznadija et al., Cell Death Differ 2009 (Adenoma...) : We explored the relationship between activated Wnt signaling and MYB in regulating MYC and found activated beta-catenin in combination with MYB induces robust upregulation of MYC promoter activity, as well as endogenous MYC mRNA and protein expression, in human cells
Schmeisser et al., J Biol Chem 2009 : Upon N-methyl-D-aspartate receptor dependent activation, LAPSER1 and beta-catenin comigrate from the postsynaptic density to the nucleus and induce the transcription and translation of known beta-catenin target genes, including Tcfe2a and c-Myc
Kaur et al., Neoplasia (New York, N.Y.) 2010 (Colorectal Neoplasms) : Other studies, therefore, were performed only in SW480 cells where silibinin significantly decreased beta-catenin dependent T-cell factor-4 (TCF-4) transcriptional activity and protein expression of beta-catenin target genes such as c-Myc and cyclin D1