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NAMPT — PRKAB2

Text-mined interactions from Literome

Fulco et al., Dev Cell 2008 : Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK mediated regulation of Nampt ... Activated AMPK was required to promote GR-induced transcription of the NAD+ biosynthetic enzyme Nampt
Costford et al., Am J Physiol Endocrinol Metab 2010 (Diabetes Mellitus, Type 2...) : Activation of AMPK via AICAR resulted in an approximately 3.4-fold increase in NAMPT mRNA ( P < 0.05 ) as well as modest increases in NAMPT protein ( P < 0.05 ) and mitochondrial content ( P < 0.05 )
Caton et al., Diabetes Obes Metab 2011 (Disease Models, Animal...) : Metformin increased AMPK activity in WAT of db/db mice and in metformin treated adipocytes, with increased NAMPT , SIRT1 and circadian component expression
Bowlby et al., PloS one 2012 : Nampt blockade resulted in reduced ATP levels and concomitant activation of AMP activated protein kinase (AMPK) and phosphorylation of acetyl-CoA carboxylase (ACC)
Xiao et al., J Cell Physiol 2013 (Cardiovascular Diseases...) : Visfatin also up-regulated the protein levels of phosphorylated AMPK , and the anti-apoptotic action of visfatin was attenuated by the AMPK-specific inhibitor compound C