Gene interactions and pathways from curated databases and text-mining

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MTOR — NF1

Text-mined interactions from Literome

Banerjee et al., Cancer Res 2010 : The NF1 gene product neurofibromin negatively regulates Ras and mammalian target of rapamycin (mTOR) signaling , prompting clinical trials to evaluate the ability of Ras and mTOR pathway inhibitors to arrest NF1 associated tumor growth
Dasgupta et al., Cancer Res 2005 (Astrocytoma...) : Recent studies from our laboratory have shown that neurofibromin also regulates the mammalian target of rapamycin activity in a Ras dependent fashion, and that the rapamycin mediated mammalian target of rapamycin inhibition ameliorates the Nf1-/- astrocyte growth advantage
Hegedus et al., Cancer Res 2008 (Disease Models, Animal...) : Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling , we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume ... Because neurofibromin negatively regulates mammalian target of rapamycin (mTOR) signaling, we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume