Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gibbs et al., Int J Biochem Cell Biol 2012 (Congenital Disorders of Glycosylation...) : Furthermore, we observed that nitric oxide synthase activity was dependent on mTOR in these myeloid cells and involved in HIF-1a accumulation mediated by endosomal toll-like receptor 7/8 triggering in THP-1 cells as well as IgE dependent basophil, but not mast cell, responses
Dello Russo et al., Biochem Pharmacol 2009 : Moreover, mTOR inhibitors reduced NOS activity and NOS2 expression induced by cytokines, but not those induced by LPS
Kristof et al., J Biol Chem 2003 (Inflammation) : The role of mTOR and PI3K in the activation of human inducible nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells
Lisi et al., Journal of neuroinflammation 2011 : In this study the effects of mTOR inhibition on iNOS regulation were evaluated in astrocytes ... In this experimental paradigm mTOR activation did not significantly affect astrocyte iNOS activity, but mTOR pathway was involved in the regulation of iNOS expression