UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

NSMAF — TNF

Pathways - manually collected, often from reviews:

NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → sTNF-alpha/TNFR1A complex (TNFRSF1A-TNF) (modification, collaborate)
Adam-Klages et al., Cell 1996 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → FAN (NSMAF) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → NSMASE (SMPD2) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A complex (TNFRSF1A-TNF) → FAN (NSMAF) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → TNF-alpha (TNF) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: assay, physical interaction
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → FAN (NSMAF) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: assay, physical interaction
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → TNFR1A (TNFRSF1A) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: assay, physical interaction
NCI Pathway Database Ceramide signaling pathway: TNF-alpha (TNF) → FAN (NSMAF) (modification, collaborate) Adam-Klages et al., Cell 1996 *
Evidence: assay, physical interaction
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → None (modification, activates) Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) (modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → Neutral sphingomyelinase II (SMPD3) (modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) (modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
NCI Pathway Database Ceramide signaling pathway: TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF) → Acid Sphingomyelinase (SMPD1) (modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → RACK1 (GNB2L1) (modification, collaborate) Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF) → sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF) (modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : RACK1 (GNB2L1) → sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF) (modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction