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CDK2 — ORC4

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDK2 → ORC4 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999, Méndez et al., Mol Cell 2002
• Reactome Reaction: CDK2 → ORC4 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999

Text-mined interactions from Literome

Findeisen et al., Eur J Biochem 1999 : We find that chromatin binding of ORC , Cdc6, and MCM proteins does not require cyclin dependent kinase activities
Fernández-Cid et al., Mol Cell 2013 : Importantly, CDK dependent phosphorylation of ORC inhibits OCM establishment to ensure once per cell cycle replication