Gene interactions and pathways from curated databases and text-mining

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CASP5 — PARG

Text-mined interactions from Literome

Affar et al., J Biol Chem 2001 : The cleavage sites identified by site directed mutagenesis are DEID ( 256 ) downward arrow V and the unconventional site MDVD ( 307 ) downward arrow N. Kinetic studies have shown similar maximal velocity ( V ( max ) ) and affinity ( K ( m ) ) for both full-length PARG and its apoptotic fragments, suggesting that caspase-3 may affect PARG function without altering its enzymatic activity
Feng et al., Molecular cancer 2012 (Breast Neoplasms) : AIF silencing in these cells led to profound protection from chemotherapy, which demonstrates that the increased cell death after PARG silencing and caspase inhibition was mediated by AIF