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EPO — PCBD1
Text-mined interactions from Literome
Wojchowski et al., Exp Cell Res 1999
(Polycythemia) :
Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential for the development of committed erythroid progenitor cells beyond the colony forming unit-erythroid stage, and this clearly involves
Epo 's
inhibition of
programmed cell death (PCD)
Zhuang et al., J Biol Chem 1995
:
Epo dependent inhibition of
PCD also is shown to be blocked by ectopic expression of kinase-deficient dominant negative forms of Jak2 ( Jak2 delta VIII and Jak2-829 ), further underlining a role of this membrane-proximal subdomain of the Epo receptor in the inhibition of PCD