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MLST8 — PI3
Text-mined interactions from Literome
Roux et al., Proc Natl Acad Sci U S A 2004
(MAP Kinase Signaling System...) :
Phosphatidylinositol 3-kinase (PI3K) inactivates the tumor suppressor complex and
enhances mTOR signaling by means of phosphorylation of tuberin by Akt
Kumar et al., Mol Cell Biol 2008
:
Since little is known about the
role of either rictor or
mTORC2 in
PI-3 kinase mediated physiological processes in adult animals, we generated muscle-specific rictor knockout mice
Tzatsos et al., J Biol Chem 2009
:
Overall, these data provide new insights in the molecular mechanisms by which
mTORC1 inhibits
PI 3-kinase/Akt signaling at the level of IRS-1 and suggest that mTOR signaling toward Akt is scaffold dependent
Lipinski et al., Dev Cell 2010
(MAP Kinase Signaling System) :
In a genome-wide human siRNA screen, we demonstrate that under normal nutrient conditions upregulation of autophagy requires the type III
PI3 kinase, but not
inhibition of
mTORC1 , the essential negative regulator of starvation induced autophagy
Razmara et al., Cell communication and signaling : CCS 2013
:
Inhibition of
phosphatidylinositol 3-kinase (PI3K) inhibited PDGF-BB activation of both
mTORC1 and mTORC2 ... Inhibition of
phosphatidylinositol 3-kinase (PI3K) inhibited PDGF-BB activation of both mTORC1 and
mTORC2
Fortress et al., Learn Mem 2013
(MAP Kinase Signaling System) :
Here, we asked whether the enhancement of object recognition memory consolidation produced by dorsal hippocampal infusion of 17ß-estradiol ( E ( 2 ) ) is dependent on mTOR signaling in the dorsal hippocampus, and whether E ( 2 ) -induced
mTOR signaling is
dependent on dorsal hippocampal
phosphatidylinositol 3-kinase (PI3K) and extracellular signal regulated kinase ( ERK ) activation