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PI3 — RPTOR

Text-mined interactions from Literome

Roux et al., Proc Natl Acad Sci U S A 2004 (MAP Kinase Signaling System...) : Phosphatidylinositol 3-kinase (PI3K) inactivates the tumor suppressor complex and enhances mTOR signaling by means of phosphorylation of tuberin by Akt
Tzatsos et al., J Biol Chem 2009 : Overall, these data provide new insights in the molecular mechanisms by which mTORC1 inhibits PI 3-kinase/Akt signaling at the level of IRS-1 and suggest that mTOR signaling toward Akt is scaffold dependent
Lipinski et al., Dev Cell 2010 (MAP Kinase Signaling System) : In a genome-wide human siRNA screen, we demonstrate that under normal nutrient conditions upregulation of autophagy requires the type III PI3 kinase, but not inhibition of mTORC1 , the essential negative regulator of starvation induced autophagy
Razmara et al., Cell communication and signaling : CCS 2013 : Inhibition of phosphatidylinositol 3-kinase (PI3K) inhibited PDGF-BB activation of both mTORC1 and mTORC2
Fortress et al., Learn Mem 2013 (MAP Kinase Signaling System) : Here, we asked whether the enhancement of object recognition memory consolidation produced by dorsal hippocampal infusion of 17ß-estradiol ( E ( 2 ) ) is dependent on mTOR signaling in the dorsal hippocampus, and whether E ( 2 ) -induced mTOR signaling is dependent on dorsal hippocampal phosphatidylinositol 3-kinase (PI3K) and extracellular signal regulated kinase ( ERK ) activation