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PIK3R1 — TLR2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lasunskaia et al., J Leukoc Biol 2006
(Tuberculosis) :
Mycobacteria directly induce cytoskeletal rearrangements for macrophage spreading and polarization through
TLR2 dependent
PI3K signaling ... The obtained data demonstrate that the direct effect of mycobacteria on macrophage shape might be mediated through
TLR2 dependent
PI3K activation
Guiducci et al., J Exp Med 2008
:
We show that
PI3K is
activated by
TLR stimulation in primary human pDCs and demonstrate, using specific inhibitors, that PI3K is required for type I IFN production by pDCs, both at the transcriptional and protein levels
Hodson et al., Adv Exp Med Biol 2009
:
Although CD40,
TLR and cytokines all
activate PI3K the BCR seems especially dependent upon PI3K signalling
Dil et al., Mol Immunol 2009
:
In this study we assess the
role of p110 delta
PI3K in TLR4,
TLR9 , or TLR4+TLR9 mediated B cell responses
Wenink et al., J Immunol 2009
:
The inhibitory effect of
TLR2 on the release of TNF-alpha but not of IL-12p70 was
mediated by
PI3K
Shen et al., Infect Immun 2010
(Listeriosis) :
Moreover, functional activation of
PI3K and Rac1 was
impaired in
TLR2 ( -/- ) and MyD88 ( -/- ) macrophages
Li et al., J Neuroimmunol 2011
(Chronic Disease...) :
Furthermore, stimulation of
TLR2 by PGN
induces protection from stress induced reduction in the number of splenocytes through
PI3K ... Collectively, our study thus demonstrates that stimulation of
TLR2 mediated
PI3K signaling attenuates splenocyte reduction induced by stress, and that ß-arrestin 2 modulates TLR2 mediated immune response following stress
Toubiana et al., J Biol Chem 2011
:
We report here that IMPDHII
plays an important role in the negative regulation of
TLR2 signaling by modulating
PI3K activity
Schmid et al., Cancer Cell 2011
(Disease Progression...) :
Receptor tyrosine kinases and
TLR/IL1Rs unexpectedly
activate myeloid cell
PI3k? , a single convergent point promoting tumor inflammation and progression
Lu et al., J Immunol 2011
(Infarction, Middle Cerebral Artery...) :
More significantly, either
TLR2 deficiency or
PI3K inhibition with LY29004 abolished the protection by Pam3CSK4
Troutman et al., Cell cycle (Georgetown, Tex.) 2012
(Inflammation) :
Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on
TLR mediated activation of
PI3K and its impact on regulating cellular processes