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AKT2 — POU5F1

Text-mined interactions from Literome

Kim et al., Stem Cells 2008 : The selenium induced activation of extracellular regulated kinases 1/2 and Akt in ATSCs resulted in a subsequent induction of the expression of stemness transcription factors, particularly Rex1, Nanog, and Oct4 , along with definitive demethylation on regulatory regions of Rex-1, Nanog, and Oct4
Wang et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : We further demonstrate that Oct4 overexpression induced activation of TCL1, AKT , and ABCG2 to mediate chemoresistance, which can be overcome by addition of the PI3K/AKT inhibitor ; therefore, a direct pathway of Oct4-TCL1-AKT-ABCG2 or a combination of Oct4-TCL1-AKT with the AKT-ABCG2 pathway could be a potential new mechanism involved in liver cancer cell chemoresistance
Barale et al., Stem Cells Dev 2012 : siRNA technology was also applied to demonstrate the role of Akt activity in mediating HG-induced Oct-4 and Nanog expression as well as spheroid formation