Gene interactions and pathways from curated databases and text-mining

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IRF6 — PRG3

Text-mined interactions from Literome

Fenton et al., Osteoarthritis Cartilage 2000 (Horse Diseases...) : The addition of 25 mg/ml of glucosamine prevented the increase in nitric oxide production, proteoglycan release and MMP activity induced by LPS or rhIL-1
Aota et al., Cell Tissue Res 2006 : In articular chondrocytes, LPS strongly suppressed cell proliferation and proteoglycan synthesis in a dose dependent manner and stimulated proteoglycan degradation ... Thus, LPS suppressed proteoglycan synthesis and stimulated proteoglycan degradation by articular chondrocytes and nucleus pulposus cells
Bobacz et al., Arthritis Rheum 2007 : In murine and human articular chondrocytes, but not in chondrocytes derived from TLR-4 ( -/- ) mice, stimulation with LPS resulted in a decrease in total proteoglycan synthesis
Yeh et al., J Rheumatol 1995 : IL-4 significantly reduced the cartilage proteoglycan degradation induced by IL-1 alpha, TNF-alpha, TNF-alpha plus IL-1 alpha, or LPS ( 50 % inhibitory concentration, IC50 for IL-4 ranged from about 15 to 50 ng/ml )
Henrotin et al., J Rheumatol 1998 : As well, proteoglycan synthesis was profoundly inhibited by IL-1beta and LPS