Gene interactions and pathways from curated databases and text-mining

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IL10 — PRKACB

Text-mined interactions from Literome

Yang et al., J Immunol 2003 (Glioma) : However, KT5720, a selective PKA inhibitor, reduced neither anti-Fas triggered nor glioma associated IL-10 expression
Ha et al., J Leukoc Biol 2005 : Further characterization of the response to PSG17 indicated that cyclic adenosine monophosphate dependent protein kinase A (PKA) is involved in the up-regulation of IL-10 and IL-6, and it is not required for the induction of TGF-beta(1)
Park et al., J Leukoc Biol 2008 : Inhibition of either ERK1/2 or PKA activity prevented gAcrp stimulated CREB phosphorylation, as well as gAcrp stimulated IL-10 promoter activation
Seo et al., Exp Mol Med 2008 : Further, we obtained evidence of crosstalk between P2 receptors, in a situation where intracellular Ca ( 2+ ) release and/or cAMP activated PKA were the main contributors to extracellular ATP- ( or ADP ) -mediated IL-10 expression, and IL-10 production was down-regulated by either MRS2179 ( a P2Y ( 1 ) antagonist ) or 5'-AMPS ( a P2Y ( 11 ) antagonist ), indicating that both the P2Y(1) and P2Y(11) receptors are major receptors involved in IL-10 expression
Pongratz et al., Ann Rheum Dis 2012 (Arthritis, Experimental) : Interleukin 10 (IL-10) producing B cells suppress arthritis and are a potential target of the SNS because ( 1 ) B cells express functional ß ( 2 ) -adrenoceptors ( ß ( 2 ) ARs ) and ( 2 ) IL-10 , at least in monocytes/macrophages, is regulated in a cAMP/PKA/CREB dependent manner
Lieskovska et al., Parasite Immunol 2012 : Saliva induced enhancement of IL-10 was not observed in the presence of specific inhibitor of Protein Kinase A (PKA) , H-89, suggesting the involvement of PKA pathway in IL-10 production