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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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AKT1 — PRKAG1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Youn et al., Circ Res 2009 : These data indicate that AMPK and AKT are both downstream of PI3K and that AKT activation is partially dependent on AMPK
King et al., Am J Physiol Heart Circ Physiol 2005 (Hyperglycemia) : Previous studies have demonstrated that AMPK can be inhibited by protein kinase B (PKB) ; however, PKB was activated by dobutamine and the elevated insulin that accompanied hyperglycemia, but there was no effect on AMPK activity
Davila et al., Cell Death Differ 2012 : The activation of AMPK reduced AKT activation, and led to dephosphorylation and nuclear translocation of FOXO3
Sag et al., J Immunol 2008 (Inflammation) : In addition, we found that AMPK negatively regulated LPS induced IkappaB-alpha degradation and positively regulated Akt activation, accompanied by inhibition of glycogen synthase kinase beta and activation of CREB
Castillo-Pichardo et al., Nutr Cancer 2012 (Breast Neoplasms) : RQC was found to reduce Akt activity, induce the activation of AMPK , and inhibit mTOR signaling in breast cancer cells
Tong et al., Mol Carcinog 2012 : Through experiments with over-expression of constitutively active Akt and knockdown of LKB1 expression by siRNAs, we further found that the activation of AMPK by apigenin was not dependent on its inhibition of Akt , and was independent of the activation of upstream kinase LKB1
Procopio et al., Endocrinology 2009 : Whether leptin promotes eNOS activation via AMPK dependent activation of Akt , and which of the two AMPKalpha catalytic subunits is involved, remains unknown
Becker et al., Diabetes 2010 (Body Weight...) : Chemerin reduced insulin stimulated Akt1 phosphorylation and activation of 5'AMP activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin stimulated AMPK activation in the liver and gonadal adipose tissue
Memmott et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Carcinoma...) : In lung tissue, metformin did not activate AMPK but inhibited phosphorylation of insulin-like growth factor-I receptor/insulin receptor ( IGF-1R/IR ), Akt , extracellular signal regulated kinase ( ERK ), and mTOR
Pu et al., J Lipid Res 2011 : Weakening AMPK activity reduced phosphorylation of Akt but not ERK1/2, and Akt inhibitor could not affect ERK1/2 activation either
Berggreen et al., Am J Physiol Endocrinol Metab 2009 : In summary, we propose that PKB is required for the positive effects of insulin on lipid storage and that regulation of PDE3B and AMPK by PKB is important for these effects
Chan et al., J Biol Chem 2008 (Cardiomegaly) : Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt , thus suppressing protein synthesis and gene transcription
Ouchi et al., J Biol Chem 2004 (Neovascularization, Pathologic) : Dominant negative AMPK also inhibited adiponectin induced Akt phosphorylation, suggesting that AMPK is upstream of Akt
Suh et al., Carcinogenesis 2010 (Prostatic Neoplasms) : Fisetin also activated the mTOR repressor TSC2 through inhibition of Akt and activation of AMPK
Liu et al., Cell Signal 2010 : Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface ... In the presence of berberine, PKCzeta controlled AMPK activation and AMPK blocked PKB activity in perinuclear region
Lieberthal et al., American journal of physiology. Renal physiology 2011 : Protection by AMPK appears to be due not to AMPK mediated conservation of cell energy stores, but rather, at least in part, to AMPK mediated activation of Akt
Omar et al., Cell Signal 2009 : Here we investigated the roles of PDE3B, PDE4, protein kinase B (PKB) and the exchange protein activated by cAMP 1 ( Epac1 ), as well as lipolysis, in the regulation of AMPK in primary rat adipocytes ... Adenovirus mediated overexpression of PDE3B and constitutively active PKB both resulted in greatly reduced isoproterenol induced phosphorylation of AMPK at T172
Zakikhani et al., Breast Cancer Res Treat 2010 (Breast Neoplasms) : siRNA methods confirmed that reduction of AMPK levels attenuates both the IRS-1 Ser ( 789 ) phosphorylation and the inhibition of AKT activation associated with metformin exposure
Priebe et al., Gynecol Oncol 2011 (Ovarian Neoplasms) : Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells
Kovacic et al., J Biol Chem 2003 : Because insulin is able to activate Akt and inactivate AMP activated protein kinase (AMPK) in the heart, we hypothesized that Akt can regulate the activity of AMPK ... Taken together, this study suggests that there is cross-talk between the AMPK and Akt pathways and that Akt activation can lead to decreased AMPK activity
Tao et al., Journal of molecular signaling 2010 : Thus, this result suggests that AMPK activation of Akt is not mediated by regulating phosphatase and tensin homologue (PTEN)
Ning et al., Endocrinology 2011 (Diabetes Mellitus, Experimental...) : Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells
Leclerc et al., Journal of molecular signaling 2010 : AMPK induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia ... We found that AICAR induced AMPK activation resulted in up-regulation of P-Akt ( Ser473 and Thr308 ) and decrease of P-mTOR ( Ser2448 ) expression and downstream signaling ... We determined that activation of P-Akt ( Thr308 ) was mediated by AMPK induced IGF-1R activation via phosphorylation of the insulin receptor substrate-1 (IRS-1) at Ser794 ... Co-treatment of AICAR plus HNMPA ( AM ) 3 prevented AMPK induced up-regulation of P-Akt ( Thr308 ) but did not alter the activation of P-Akt ( Ser473 ) ... Inhibition of AMPK using compound-C resulted in decreased P-Akt expression at both residues, suggesting a central role for AMPK in Akt activation
Kuznetsov et al., Mol Cancer Ther 2011 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Under these conditions, the concomitant inhibition of Akt , a cellular antagonist of AMPK, leads to further upregulation of AMPK activity and alleviates AICAr plus MTX induced ER stress and apoptosis
Baumann et al., Exp Cell Res 2007 (Multiple Myeloma) : Activation of AMPK inhibited basal extracellular signal regulated kinase ( ERK ), mammalian target of rapamycin (mTOR) and P70S6 kinase ( P70S6K ) as well as AKT phosphorylation, and blocked IL-6, IGF-1, and HS-5 stromal cell conditioned medium induced increase of cell growth
Suzuki et al., Mol Cell 2013 : Surprisingly, PI3K-Akt signaling, which is a major anabolic signaling and normally inhibits GSK3 activity, promotes GSK3 phosphorylation and inhibition of AMPK , thus revealing how AMPK senses anabolic environments in addition to cellular energy levels
Ginion et al., Am J Physiol Heart Circ Physiol 2011 (Insulin Resistance) : In conclusion, although the insulin sensitizing effect of AMPK on PKB/Akt is explained by the inhibition of the insulin induced negative feedback loop, its effect on glucose uptake is independent of this mechanism ... In conclusion, although the insulin sensitizing effect of AMPK on PKB/Akt is explained by the inhibition of the insulin induced negative feedback loop, its effect on glucose uptake is independent of this mechanism
Choi et al., J Cell Physiol 2013 (Neoplasms) : Furthermore, whereas Compound C ( an AMPK inhibitor ), AMPK-DN ( AMPK-dominant negative ) mutant, and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , TCN ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA inhibited the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 MAPK ... Furthermore, whereas Compound C ( an AMPK inhibitor ), AMPK-DN ( AMPK-dominant negative ) mutant, and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , TCN ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA inhibited the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 MAPK
Huang et al., Int J Oncol 2013 : In SK-HEP-1 cells, kaempferol increased the protein levels of p-AMPK , LC3-II, Atg 5, Atg 7, Atg 12 and beclin 1 as well as inhibited the protein levels of CDK1, cyclin B, p-AKT and p-mTOR
Dubbelhuis et al., FEBS Lett 2002 : Insulin dependent phosphorylation of protein kinase B is not affected by AMPK activation
Liu et al., Biochim Biophys Acta 2012 (Insulin Resistance) : Consistent with this, inhibition of AMPK by compound C induced an enhanced phosphorylation of both S6K1 and Akt , and silencing of S6K1 with siRNA showed no effect on Akt phosphorylation in both the absence and presence of palmitate cultured myotubes
DeSalvo et al., Mol Cancer Res 2012 (Leukemia, B-Cell...) : In addition, we find that pharmacologic and genetic Akt inhibition upregulates P-AMPK , downregulates UPR, and sensitizes ALL cells to remarkably low doses of 2-DG ( 0.5 mmol/L ), inducing 85 % cell death and overcoming the relative resistance of T-ALL
Pulinilkunnil et al., J Biol Chem 2011 : Both PKA and AKT inhibitors attenuated AMPK Ser ( 485/491 ) phosphorylation resulting from a-adrenergic blockade and prevented decreases in AMPK activity
Memmott et al., Cancer Res 2008 (Carcinoma, Non-Small-Cell Lung...) : Here, we show that lipid based Akt inhibitors, phosphatidylinositol ether lipid analogues ( PIA ), activate AMPK independently of LKB1 ... PIAs activated AMPK in LKB1-mutant non-small cell lung cancer ( NSCLC ) cell lines with similar concentration dependence as that required to inhibit Akt ... However, AMPK activation was independent of Akt inhibition
Carvalho et al., J Clin Endocrinol Metab 2011 (Myocardial Reperfusion Injury...) : However, there was no evidence for AKT dependent AMPK inhibition