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AKT2 — PSEN1

Text-mined interactions from Literome

Baki et al., EMBO J 2004 (Alzheimer Disease...) : Furthermore, conditions that inhibit this association prevent the PS1 induced PI3K/Akt activation, indicating that PS1 stimulates PI3K/Akt signaling by promoting cadherin/PI3K association ... PS1 FAD mutations inhibit the PS1 dependent PI3K/Akt activation, thus promoting GSK-3 activity and tau overphosphorylation at AD-related residues
Baki et al., J Neurosci 2008 (Alzheimer Disease...) : The role of presenilin-1 (PS1) in neuronal phosphatidylinositol 3-kinase (PI3K)/Akt signaling was investigated in primary neuronal cultures from wild-type ( WT ) and PS1 null (PS1-/-) embryonic mouse brains