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NOTCH1 — PSEN2

Pathways - manually collected, often from reviews:

• KEGG Notch signaling pathway: Complex of APH1A-NCSTN-PSEN1-PSEN2-PSENEN → NOTCH1/NOTCH2/NOTCH3/NOTCH4 (protein-protein, activation)
  
• Reactome Reaction: NOTCH1 → PSEN2 (reaction) De Strooper et al., Nature 1999, Huppert et al., Nature 2000*, Fortini et al., Nat Rev Mol Cell Biol 2002, Rustighi et al., Nat Cell Biol 2009*, Schroeter et al., Nature 1998
• WikiPathways Notch Signaling Pathway: APH1A/APH1B/TNF/PSEN1/PSEN2/NCSTN → NOTCH2/NOTCH3/NOTCH4/NOTCH1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PSEN2 — NOTCH1 (in vivo) Saxena et al., J Biol Chem 2001
• STRING interaction: NOTCH1 — PSEN2 (interaction, mapped from reactome)
• STRING interaction: PSEN2 — NOTCH1 (interaction, mapped from grid mint)

Text-mined interactions from Literome

Ye et al., Nature 1999 (Alzheimer Disease) : Loss of presenilin function leads to Notch/lin-12-like mutant phenotypes in Caenorhabditis elegans and to reduced Notch1 expression in the mouse paraxial mesoderm ... They also link the role of presenilin in Notch signalling to its effect on amyloid production in Alzheimer 's disease
Saxena et al., J Biol Chem 2001 : Despite a high degree of structural homology and the presenilin dependent activity of truncated Notch proteins, the extent that this reflects functional redundancy is unknown
Wang et al., Development 2003 : A presenilin dependent , signaling-competent form of Notch1 was detected in mesenchymal derivatives but not in the ureteric buds of wild-type mice
Wang et al., J Biol Chem 2004 : The intramembranous cleavage of Alzheimer beta-amyloid precursor protein and the signaling receptor Notch is mediated by the presenilin ( PS, PS1/PS2 ) -gamma-secretase complex, the components of which also include nicastrin, APH-1, and PEN-2
Real et al., Nat Med 2009 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia ( T-ALL )
Wacker et al., EMBO J 2011 : Ligand binding induces presenilin dependent cleavage of the receptor and a subsequent nuclear translocation of the Notch intracellular domain ( NICD )
Singh et al., Dev Cell 2012 : Hibris, a Drosophila nephrin homolog, is required for presenilin mediated Notch and APP-like cleavages
Levitan et al., Development 1998 : We discuss potential parallels for the role of SEL-12/presenilin in facilitating LIN-12/Notch activity and in amyloid precursor protein (APP) processing