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IFNG — PSMB10

Text-mined interactions from Literome

van Hall T et al., J Exp Med 2000 : Interferon (IFN)-gamma induces expression of three catalytically active proteasome subunits ( LMP2, LMP7, and MECL-1 ) and the proteasome associated activator PA28
Groettrup et al., Eur J Immunol 1996 : We compared the 20S proteasome subunit pattern from IFN-gamma induced and non induced mouse fibroblasts on two-dimensional gels and identified a third subunit exchange by microsequencing : the non-MHC encoded subunit MECL-1 is induced by IFN-gamma and replaces a sofar barely characterized beta subunit designated ` MC14 '
Nandi et al., J Immunol 1996 (Liver Neoplasms, Experimental) : MECL-1 transcription is increased in the presence of IFN-gamma , whereas the transcription of two other proteasome genes, Lmp-15 and Lmp-3, is not affected
Foss et al., Biochim Biophys Acta 1998 (Adenocarcinoma...) : To reveal the extent of constitutive and IFN-gamma induced expression of MECL1 , we studied MECL1 in different cell lines by Northern and Western blotting ... The two B cell lines IM9 and Reh showed high constitutive expression of MECL1 , only slightly induced by IFN-gamma stimulation ... The MECL1 protein level in the THP-1 cells increased markedly in response to IFN-gamma ... These results indicate that, similar to LMP2 and LMP7, MECL1 is constitutively expressed at high levels only in certain cell lines and can be induced by IFN-gamma in other cell lines