Gene interactions and pathways from curated databases and text-mining

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CASP8 — PTBP1

Pathways - manually collected, often from reviews:

  • BioCarta internal ribosome entry pathway: Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10) → eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2) (modification, activates)
  • BioCarta internal ribosome entry pathway: Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10) → c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2) (modification, activates)

Text-mined interactions from Literome

Zhang et al., Cell Death Differ 2009 : PTB overexpression in cardiomyocytes induced caspase activity and caspase dependent DNA fragmentation during ischemia, which is otherwise caspase independent in differentiated cardiomyocytes
Affaticati et al., Cell Death Differ 2011 (Calcium Signaling) : Sustained calcium ( Ca ( 2+ ) ) signals and caspase-3 activation in thymocytes were induced by interaction with antigen pulsed dendritic cells (DCs) and were inhibited by NMDAR antagonists MK801 and memantine
Ye et al., J Cell Sci 2013 : HDAC5-deficient mice have reduced cardiac PTB protein abundance, and HDAC inhibition in myocytes causes a reduction in endogenous expression of cellular FLICE-like inhibitory protein ( cFLIP ) and caspase dependent cleavage of PTB