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IGF1 — PTHLH
Text-mined interactions from Literome
Coxam et al., Acta Endocrinol (Copenh) 1992
:
PTHrP induced a slight but significant increase in plasma Ca and
IGF-1 concentrations measured in the hepatic vein, without changing blood flows measured in the hepatic artery and portal vein ... Thus
PTHrP increased hepatic
IGF-1 production ( 15.1 +/- 2.7 nmol.6 h-1.kg body wt-1 vs 4 +/- 1.3 nmol.6 h-1.kg body wt-1 in controls ; p less than 0.05 )
Tenta et al., Horm Metab Res 2005
(Prostatic Neoplasms) :
Consequently, we have investigated whether
IGF-1 , TGF-beta1, bFGF, IL-6, zoledronic acid and/or dexamethasone
affect the expression of the
PTHrP and type I PTH/PTHrP receptor ( PTH.1R ) in PC-3 prostate cancer cells using relative quantitative PCR and real-time PCR ( expression at mRNA level ) and immunocytochemical and immunofluorescence analysis ( expression at protein level ) ... Our data show that
IGF-1 , TGF-beta1, bFGF and IL-6 increase PTHrP mRNA expression and its perinuclear localization, while zoledronic acid ( 50 muM, 100 muM for 24 h and 48 h ) and dexamethasone
suppress PTHrP expression in PC-3 cells
Tenta et al., Anticancer Res 2006
(Bone Neoplasms...) :
Whether
IGF-1 , TGF beta 1, bFGF, IL-6 and zoledronic acid
affect the expressions of
PTHrP and PTH.1R in MG-63 osteoblast-like osteosarcoma cells was investigated in this study ... Our data showed that primarily
IGF-1 , TGF beta 1 and IL-6 ( up to 25 ng/ml for 48 h )
increased PTHrP mRNA expression and modified its perinuclear localization, while zoledronic acid ( up to 100 microM for 48 h ) inhibited cell proliferation and suppressed PTHrP expression in the MG-63 osteosarcoma cells
Sebag et al., Am J Physiol 1994
:
To investigate whether these factors were acting at the transcriptional level, we performed nuclear run-on assays and demonstrated that
IGF-I increased
PTHRP gene transcription whereas hydrocortisone and 1,25 ( OH ) 2D3 inhibited this effect
Kawane et al., Endocrinology 1999
:
IGF-I inhibition of
PTH/PTHrP receptor mRNA expression in UMR-106 cells was abrogated completely by pretreatment with cycloheximide, an inhibitor of protein synthesis